6β-hydroxy Testosterone
| 规格 | 价格 | 货期 | 数量 |
|---|---|---|---|
| 5mg | ￥2275.00 | 10-15工作日发货 |
特色产品
- 适用于流式细胞仪和荧光显微镜检测
- 准确区分活细胞/凋亡细胞/坏死细胞
- 用于免疫印迹和质谱分析等后续操作
- 适用于30 KDa-130 KDa大小的蛋白
- 对细胞无毒性
- 步骤更简单，无需有机溶剂
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
- 优异的扩增效率、可重复性和稳定性
- 卓越的灵敏度和准确性，操作简单
- 优化的缓冲液和T7 RNA聚合酶混合物
- 20 μL反应体系可获得更高的RNA产量
产品描述
CYP3A4 and CYP3A5 are cytochrome P450 enzymes whose expression is induced by glucocorticoids and certain xenobiotics, including many drugs and chemical carcinogens[1]. They mediate the metabolism of xenobiotics and certain intrinsic biotin, including steroid hormones[2].
6β-hydroxytestosterone is the main metabolite produced from testosterone through the action of CYP3A4 and CYP3A5, accounting for 75-80% of all metabolites formed by testosterone[2,3].
References:
[1]. Cooper B W, Cho T M, Thompson P M, et al. Phthalate induction of CYP3A4 is dependent on glucocorticoid regulation of PXR expression. Toxicological Sciences, 2008, 103(2): 268-277.
[2]. Draper A J, Madan A, Smith K, et al. Development of a non-high pressure liquid chromatography assay to determine testosterone hydroxylase (CYP3A) activity in human liver microsomes. Drug Metabolism and Disposition, 1998, 26(4): 299-304.
[3]. Capdevila J H, Karara A, Waxman D J, et al. Cytochrome P-450 enzyme-specific control of the regio- and enantiofacial selectivity of the microsomal arachidonic acid epoxygenase. The Journal of Biological Chemisty, 1990, 265: 10865-10871.
产品性质
| 物理外观 | A crystalline solid |
| CAS号 | 62-99-7 |
| 分子式 | C19H28O3 |
| 分子量 | 304.42 |
| 化学名称 | (6R,8R,9S,10R,13S,14S,17S)-6,17-dihydroxy-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one |
| 溶解度 | ≤1mg/ml in acetonitrile;1mg/ml in ethanol;1mg/ml in methanol |
| SMILES | C[C@]12[C@]([H])([C@@]3(C[C@H](C4=CC(CC[C@@]4([C@]3(CC2)[H])C)=O)O)[H])CC[C@@H]1O |
| 存储条件 | -20°C |
| 运输条件 | 蓝冰 |
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