Angeli’s Salt

Angeli’s salt is regarded as a classical nitroxyl (NO-) donor, but under certain conditions evolution of NO is also observed[1]. It spontaneously dissociates in a pH-dependent, first-order process with a half-life of 2.3 minutes at 37°C (pH 7.4) to liberate 0.54 moles of NO per mole of parent compound[1,2].

References:

[1]. Maragos C M, Morley D, Wink D A, et al. Complexes of ∙NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects. Journal of Medicinal Chemistry, 1991, 34(11): 3242-3247.

[2]. Keefer L K, Nims R W, Davies K M, et al. “NONOates” (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: Convenient nitric oxide dosage forms. Methods in Enzymology, 1996, 268: 281-293.