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PDM 2

 
Catalog No.
C5219
有效的选择性芳基烃受体(AhR)拮抗剂
组合的产品项目
规格价格库存 数量
50mg
¥ 1,745.00
Ship with 10-15 days
100mg
¥ 3,054.00
Ship with 10-15 days

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A

背景

Ki = 1.2 nM

PDM 2 is a potent and selective aryl hydrocarbon receptor (AhR) antagonist.

The aryl hydrocarbon receptor (AhR) is a ligand-dependent intracellular transcription factor whose ligands include some of the most infamous xenobiotics, such as dioxin, benzo[a]pyrene, and various polyaromatics from soot and coal tar.

In vitro: In a previous screening study, it was found that the replacement of resveratrol hydroxyls by the same substituent produced compounds with the following order of affinity: OH (resveratrol) , OMe < F < CF3 < Cl (PDM 2). PDM 2 exhibited a Ki of 1.25 for AhR and no affinity for ER, indicating that replacement of hydroxyl with chloride could abolish binding on ER and dramatically increase the affinity for AhR. Moreover, among its analogs PDM 2 was the most potent AhR antagonists in this series, being 10-fold more efficient than resveratrol. PDM 2, devoid of measurable affinity for ER, did not display any effect on ER-driven transcription. Therefore, PDM 2 was considered as a selective AhR modulator with regard to ER. In addition, its trimethoxylated derivatives and 3,5-methoxy derivatives were able to induce cytotoxicity at doses lower than 100 nM, which was consistent with previous data. 3,5-Methoxy derivatives, however, only showed cytotoxicity at concentrations higher than 10 μM [1].

In vivo: Up to now, there is no animal in vivo data reported.

Clinical trial: So far, no clinical study has been conducted.

Reference:
[1] de Medina, P. ,Casper, R.,Savouret, J.F., et al. Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators. Journal of Medicinal Chemistry 48, 287-291 (2005).

化学属性

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt283.6
Cas No.688348-25-6
FormulaC14H9Cl3
Solubility≤2mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
Chemical Name1,3-dichloro-5-[(1E)-2-(4-chlorophenyl)ethenyl]-benzene
SDFDownload SDF
Canonical SMILESClc1ccc(cc1)\C=C/c1cc(Cl)cc(Cl)c1
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质量控制

质量控制和MSDS

批次:

化学结构

PDM 2