Pamoic acid disodium salt
| 规格 | 价格 | 货期 | 数量 |
|---|---|---|---|
| 50mg | ￥1890.00 | 现货 |
特色产品
- 适用于流式细胞仪和荧光显微镜检测
- 准确区分活细胞/凋亡细胞/坏死细胞
- 用于免疫印迹和质谱分析等后续操作
- 适用于30 KDa-130 KDa大小的蛋白
- 对细胞无毒性
- 步骤更简单，无需有机溶剂
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
- 优异的扩增效率、可重复性和稳定性
- 卓越的灵敏度和准确性，操作简单
- 优化的缓冲液和T7 RNA聚合酶混合物
- 20 μL反应体系可获得更高的RNA产量
产品描述
Pamoic acid disodium salt, a supposedly inactive component in many formulations of drugs used to modulate release, is a potent agonist of the orphan receptor GPR35. GPR35 is a class A, rhodopsin-like G protein-coupled receptor (GPCR), strongly expressed in the lower intestine and colon, dorsal root ganglia, as well as a variety of immune cells including monocytes and dendritic cells. Targeting GPR35 provides potential therapeutic opportunities in a range of conditions, such as inflammation, pain and cancer.
References:
1. Zhao P, Sharir H, Kapur A, et al. Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity. Molecular Pharmacology, 2010, 78(4): 560-568.
2. Quon T, Lin LC, Ganguly A, et al. Therapeutic Opportunities and Challenges in Targeting the Orphan G Protein-Coupled Receptor GPR35. ACS Pharmacology & Translational Science, 2020, 3(5): 801-812.
产品性质
| 物理外观 | Pale yellow solid |
| CAS号 | 6640-22-8 |
| 分子式 | C23H14Na2O6 |
| 分子量 | 432.33 |
| 小分子别名 | Pamoic acid disodium |
| 化学名称 | sodium 1,1'-methylenebis(3-carboxynaphthalen-2-olate) |
| 溶解度 | insoluble in EtOH; ≥18 mg/mL in H2O; ≥28.6 mg/mL in DMSO |
| SMILES | [O-]c1c(Cc(c(cccc2)c2cc2C(O)=O)c2[O-])c(cccc2)c2cc1C(O)=O.[Na+].[Na+] |
| 存储条件 | 室温干燥 |
| 运输条件 | 蓝冰 |
产品应用 (实验数据来自文献，APExBIO并未验证，仅供参考)
IC50和靶点
| 生物活性描述 | 帕莫酸二钠是一种强效的 GPR35 激动剂，其 EC50 值为 79 nM。帕莫酸二钠能诱导 GPR35 内化并激活 ERK1/2，EC50 值分别为 22 nM 和 65 nM。帕莫酸二钠能有效地将β-arrestin2募集到GPR35上，并具有抗痛觉作用。 |
质量控制
操作说明
APExBIO 顾客使用本产品发表的 1 篇科研文献
- 1. Jinchao Gao, Qingxiang Song, et al. "Intracerebral fate of organic and inorganic nanoparticles is dependent on microglial extracellular vesicle function." Nat Nanotechnol. 2024 Mar;19(3):376-386. PMID: 38158436
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