NVP 231
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
NVP 231是有效的和可逆的神经酰胺激酶(CerK)特异性抑制剂.放射免疫法测得,其IC50值为12 ± 2 nM[1].
NVP 231可以抑制CerK,其IC50值为12 ± 2 nM.在放射免疫测定中,100 nM NVP 231对CerK具有90%抑制.据报道,NVP 231与神经酰胺竞争,其Ki值为7.4 nM.此外,100 nM NVP 231完全抑制CIP.在过表达人CerK的COS细胞(COS-CerK)中,相对于人CerK,NVP 231对小鼠CerK具有更强的抑制作用.此外,NVP 231具有CerK特异性,对hCerK\hSphK1\hSphK2\hDAGKα\hPI3Kα\hVps34\hGCS\hSMS-1和CERT的IC50值分别为0.01 μM\100 μM\>100 μM\5 μM\>25 μM\>25 μM\>10 μM\>10 μM和>10 μM[1].
参考文献:
[1]Graf C1, Klumpp M, Habig M, Rovina P, Billich A, Baumruker T, Oberhauser B, Bornancin F. Targeting ceramide metabolism with a potent and specific ceramide kinase inhibitor. Mol Pharmacol. 2008 Oct;74(4):925-32.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 431.55 |
Cas No. | 362003-83-6 |
Formula | C25H25N3O2S |
Solubility | insoluble in H2O; ≥2.58 mg/mL in EtOH with gentle warming and ultrasonic; ≥87.6 mg/mL in DMSO with ultrasonic |
Chemical Name | N-(2-benzamido-1,3-benzothiazol-6-yl)adamantane-1-carboxamide |
SDF | Download SDF |
Canonical SMILES | C1C2CC3CC1CC(C2)(C3)C(=O)NC4=CC5=C(C=C4)N=C(S5)NC(=O)C6=CC=CC=C6 |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
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