Mycro 3
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Mycro 3是一种有效的选择Myc-Max二聚化抑制剂。Mycro 3还能抑制c-Myc的DNA结合[1]。Mycro 3可用于胰腺癌的研究[2]。Mycro 3能抑制c-Myc和Max之间的相互作用。Mycro 3具有高选择性，可抑制c-Myc/Max的二聚化和与DNA的结合。在全细胞实验中，Mycro 3对c-Myc具有高效性和选择性，对激活剂蛋白1（AP-1）的抑制活性较弱，Mycro 3的特异性优于其前者。
参考文献：
[1]. Chen BJ, Wu YL, Tanaka Y, Zhang W. Small molecules targeting c-Myc oncogene: promising anti-cancer therapeutics. Int J Biol Sci. 2014 Sep 13;10(10):1084-96. doi: 10.7150/ijbs.10190. PMID: 25332683; PMCID: PMC4202025.
[2]. Stellas D, Szabolcs M, Koul S, Li Z, Polyzos A, Anagnostopoulos C, Cournia Z, Tamvakopoulos C, Klinakis A, Efstratiadis A. Therapeutic effects of an anti-Myc drug on mouse pancreatic cancer. J Natl Cancer Inst. 2014 Oct 11;106(12):dju320. doi: 10.1093/jnci/dju320. PMID: 25306215.
| Storage | Store at -20°C |
| M.Wt | 526.88 |
| Cas No. | 944547-46-0 |
| Formula | C24H17ClF2N6O4 |
| Solubility | ≥49.2 mg/mL in DMSO |
| Chemical Name | ethyl 5-(7-(chlorodifluoromethyl)-5-(furan-2-yl)pyrazolo[1,5-a]pyrimidine-2-carboxamido)-1-phenyl-1H-pyrazole-4-carboxylate |
| SDF | Download SDF |
| Canonical SMILES | O=C(OCC)C1=C(N(N=C1)C2=CC=CC=C2)NC(C3=NN4C(C(Cl)(F)F)=CC(C5=CC=CO5)=NC4=C3)=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
