ML-356
| 规格 | 价格 | 货期 | 数量 |
|---|---|---|---|
| 1mg | ￥1444.00 | 10-15工作日发货 | |
| 5mg | ￥4995.00 | 10-15工作日发货 | |
| 10mg | ￥8967.00 | 10-15工作日发货 |
特色产品
- 适用于流式细胞仪和荧光显微镜检测
- 准确区分活细胞/凋亡细胞/坏死细胞
- 用于免疫印迹和质谱分析等后续操作
- 适用于30 KDa-130 KDa大小的蛋白
- 对细胞无毒性
- 步骤更简单，无需有机溶剂
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
- 优异的扩增效率、可重复性和稳定性
- 卓越的灵敏度和准确性，操作简单
- 优化的缓冲液和T7 RNA聚合酶混合物
- 20 μL反应体系可获得更高的RNA产量
产品描述
ML-356 is an inhibitor of the thioesterase domain of fatty acid synthase with IC50 value of 334 nM.
Fatty acid synthase (FAS) is a multi-enzyme protein that catalyzes fatty acid synthesis, fatty acids are related to energy production and storage, cellular structure ,hormones biosynthesis .A number of subsequent immunohistochemically analyses showed that increased expression of FAS is a hallmark of all major cancers including those of the prostate, the breast, the colon, and the ovaries.
In prostate cancer PC-3 cells, ML-356 blocked palmitate (the final product of fatty acids synthesis) biosynthesis, indicating that ML-356 has potential to block tumor growth in vivo because FAS is up-regulated in all the major solid tumors.
Reference:
1. R. Ardecky, M. P. Hedrick, P. Gosalia, et al. Selective inhibitors of FAS-TE. Probe Reports from the NIH Molecular Libraries Program (2010).
产品性质
| 物理外观 | A crystalline solid |
| CAS号 | 1808260-45-8 |
| 分子式 | C19H25N3O4S2 |
| 分子量 | 423.5 |
| 化学名称 | 2-ethyl-N-[4-[4-(4-morpholinylsulfonyl)phenyl]-2-thiazolyl]-butanamide |
| 溶解度 | ≤0.5mg/ml in ethanol;20mg/ml in DMSO;10mg/ml in dimethyl formamide |
| SMILES | CCC(CC)C(Nc1nc(-c(cc2)ccc2S(N2CCOCC2)(=O)=O)c[s]1)=O |
| 存储条件 | -20°C |
| 运输条件 | 蓝冰 |
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