Metronidazole
| 规格 | 价格 | 货期 | 数量 |
|---|---|---|---|
| 1mL(10 mM in DMSO) | ￥454.00 | 现货 | |
| 5g | ￥427.00 | 现货 | |
| 10g | ￥690.00 | 现货 |
特色产品
- 适用于流式细胞仪和荧光显微镜检测
- 准确区分活细胞/凋亡细胞/坏死细胞
- 用于免疫印迹和质谱分析等后续操作
- 适用于30 KDa-130 KDa大小的蛋白
- 对细胞无毒性
- 步骤更简单，无需有机溶剂
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
- 优异的扩增效率、可重复性和稳定性
- 卓越的灵敏度和准确性，操作简单
- 优化的缓冲液和T7 RNA聚合酶混合物
- 20 μL反应体系可获得更高的RNA产量
产品描述
Metronidazole is an effective inhibitor of OAT3 with IC50 of 6.51 ± 0.99 μM, Ki of 6.48 μM [1]. Also as a nitroimidazole antibiotic medication, metronidazole is used targeting anaerobic bacteria and protozoa [2].
Human Organ anion/cation transporters (OATs) are important membrane transporters, which are responsible for the cellular influx of drugs in human key tissues. Inhibitors affecting the cellular intake of transporter could make dysfunction of transporters, causing drug-drug interactions (DDIs) and bring poor effect and /or side reactions.
Transport functional assay indicated that Metronidazole potently inhibited the transport activity of OAT3 with IC50 of 6.51 ± 0.99 μM, Ki of 6.48 μM. Metronidazole could also reduce methotrexate influx via OATs and OATP1A2 consistently [1].
Reference:
[1] Lu X, Chan T, Zhu L, et al. The inhibitory effects of eighteen front-line antibiotics on the substrate uptake mediated by human Organic anion/cation transporters Organic anion transporting polypeptides and Oligopeptide transporters in in vitro models [J]. European Journal of Pharmaceutical Sciences. 2018, 115(30): 132-143.
[2] Scully BE. Metronidazole. Medical Clinic of North America. 1988, 72(3): 613-621.
产品性质
| 物理外观 | A solid |
| CAS号 | 443-48-1 |
| 分子式 | C6H9N3O3 |
| 分子量 | 171.15 |
| 化学名称 | 2-(2-methyl-5-nitroimidazol-1-yl)ethanol |
| 溶解度 | ≥11.54 mg/mL in EtOH with ultrasonic; ≥3.13 mg/mL in H2O with ultrasonic; ≥8.55 mg/mL in DMSO |
| SMILES | Cc([n]1CCO)ncc1[N+]([O-])=O |
| 存储条件 | -20°C |
| 运输条件 | 蓝冰 |
产品应用 (实验数据来自文献，APExBIO并未验证，仅供参考)
IC50和靶点
| 生物活性描述 | 甲硝唑是一种口服活性硝基咪唑类抗生素。甲硝唑可穿过血脑屏障。甲硝唑可用于厌氧菌感染的研究。 |
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