MD2-IN-1
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
MD2-IN-1是髓样分化蛋白2(MD2)的抑制剂，对重组人MD2(rhMD2)的KD值为189 μM。用不同剂量的MD2-IN-1预处理可剂量依赖性地降低FITC-LPS与细胞表面膜中MD2的结合，就平均荧光强度而言，在10 μM处抑制率为65%。 LPS治疗组的肺湿/干重比明显高于对照组，并且 MD2-IN-1治疗减少了LPS诱导的肺水肿。 MD2-IN-1的施用明显降低了LPS诱导的BALF中蛋白质浓度的增加。LPS还会引起可观察到的肺组织病理学变化，包括炎症浸润区域、出血、间质水肿、肺泡壁增厚和肺组织破坏。这些组织病理学变化在MD2-IN-1治疗组中得到改善[1]。
参考文献：
[1]. Zhang Y, Wu J, Ying S, Chen G, Wu B, Xu T, Liu Z, Liu X, Huang L, Shan X, Dai Y, Liang G. Discovery of new MD2 inhibitor from chalcone derivatives with anti-inflammatory effects in LPS-induced acute lung injury. Sci Rep. 2016 Apr 27;6:25130. doi: 10.1038/srep25130. PMID: 27118147; PMCID: PMC4846832.
| Storage | Store at -20°C |
| M.Wt | 358.39 |
| Cas No. | 111797-22-9 |
| Formula | C20H22O6 |
| Solubility | ≥34.4 mg/mL in DMSO |
| Chemical Name | (E)-1-(3,4-dimethoxyphenyl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one |
| SDF | Download SDF |
| Canonical SMILES | O=C(C1=CC=C(OC)C(OC)=C1)/C=C/C2=CC(OC)=C(OC)C(OC)=C2 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
