Maduramicin
| 规格 | 价格 | 货期 | 数量 |
|---|---|---|---|
| 5mg | ￥3964.00 | 10-15工作日发货 | |
| 25mg | ￥13575.00 | 10-15工作日发货 |
特色产品
- 适用于流式细胞仪和荧光显微镜检测
- 准确区分活细胞/凋亡细胞/坏死细胞
- 用于免疫印迹和质谱分析等后续操作
- 适用于30 KDa-130 KDa大小的蛋白
- 对细胞无毒性
- 步骤更简单，无需有机溶剂
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
- 优异的扩增效率、可重复性和稳定性
- 卓越的灵敏度和准确性，操作简单
- 优化的缓冲液和T7 RNA聚合酶混合物
- 20 μL反应体系可获得更高的RNA产量
产品描述
IC50: 20.7 μM: inhibits ATP synthesis in spinach chloroplasts [1].
IC50: 96.6 μM: blocks H+ uptake in spinach chloroplasts [1].
Maduramicin, a natural polyether antibiotic, is cytotoxic against Cryptosporidium spp. and Plasmodium gametocytes, isolated from the actinomycete Actinomadura rubra. As a broad-spectrum anticoccidial, maduramicin, which is commonly used in veterinary medicine as an anti-coccidial agent, is active against Treponema and Cryptosporidium. Maduramicin is an ionophore which can form complexes with monovalent cations with a higher affinity for K+ than Na+.
In vitro: Maduramicin concentration-dependently blocked cell growth and inhibited cell proliferation in a concentration- and time-dependent fashion in skeletal muscle cells, mouse myoblasts (C2C12) and human rhabdomyosarcoma (RD and Rh30) cells. Also, maduramicin triggered cleavage of poly ADP ribose polymerase in a concentration-dependent manner, which was the hallmark of caspase-dependent apoptosis in C2C12 and RD cells. It was determined that maduramicin caused cell death via caspase-dependent and -independent manner in C2C12 cells [2].
In vivo: Severe combined immune deficient (SCID) mice were administered with maduramicin at 3 mg/kg of body weight per day by oral gavage for 28 days. Maduramicin treatment decreased the fecal parasite load after 21 days of treatment. Also, maduramicin treatment elicited weight loss in SCID mice. In addition, Maduramicin exerted remarkable anticryptosporidial activities with concomitant moderate toxicity on SCID mice [3].
References:
[1]. Gutiérrez-Lugo, M., Lotina-Hennsen, B., Farrés, A., Sánchez, S., & Mata, R. Phytotoxic and Photosynthetic Activities of Maduramicin and Maduramicin Methyl Ester. Zeitschrift Für Naturforschung C. 1999; 54(5-6).
[2]. Chen, X., Gu, Y., Singh, K., Shang, C., Barzegar, M., Jiang, S., & Huang, S. Maduramicin Inhibits Proliferation and Induces Apoptosis in Myoblast Cells. Plos ONE.2014; 9(12): e115652.
[3]. Mead, J., You, X., Pharr, J., Belenkaya, Y., Arrowood, M., Fallon, M., & Schinazi, R. Evaluation of maduramicin and alborixin in a SCID mouse model of chronic cryptosporidiosis. Antimicrobial Agents and Chemotherapy. 1995; 39(4): 854-858.
产品性质
| 物理外观 | A solid |
| CAS号 | 79356-08-4 |
| 分子式 | C47H80O17 |
| 分子量 | 917.1 |
| 化学名称 | (2R,3S,4S,5R,6S)-6-[(1R)-1-[(2S,5R,7S,8R,9S)-2-[(2S,2'R,3'S,5R,5'R)-3'-[(2,6-dideoxy-3,4-di-O-methyl-β-L-arabino-hexopyranosyl)oxy]octahydro-2-methyl-5'-[(2S,3S,5R,6S)-tetrahydro-6-hydroxy-3,5,6-trimethyl-2H-pyran-2-yl][2,2'-bifuran]-5-yl]-9-hydroxy-2,8-d |
| 溶解度 | Soluble in DMSO |
| SMILES | CO[C@@H]1[C@@H](OC)[C@H](C)O[C@@](O[C@@H]2[C@@]([C@]3(C)CC[C@@]([C@@]4(C)O[C@@]5(C[C@H](O)[C@@H](C)[C@]([C@@H](C)[C@]6([H])O[C@@](CC(O)=O)(O)[C@@H](C)[C@H](OC)[C@H]6OC)([H])O5)CC4)([H])O3)([H])O[C@]([C@]7([H])[C@@H](C)C[C@@H](C)[C@@](C)(O)O7)([H])C2) |
| 存储条件 | -20°C |
| 运输条件 | 蓝冰 |
产品应用 (实验数据来自文献，APExBIO并未验证，仅供参考)
IC50和靶点
| 生物活性描述 | 马杜霉素（Maduramycin）是一种抗球菌药。马杜霉素通过内在和外在途径诱导鸡心肌细胞。 |
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