Lasalocid
离子载体抗生素
| 规格 | 价格 | 货期 | 数量 |
|---|---|---|---|
| 5mg | 请咨询 | 10-15工作日发货 | |
| 25mg | 请咨询 | 10-15工作日发货 |
特色产品
- 适用于流式细胞仪和荧光显微镜检测
- 准确区分活细胞/凋亡细胞/坏死细胞
- 用于免疫印迹和质谱分析等后续操作
- 适用于30 KDa-130 KDa大小的蛋白
- 对细胞无毒性
- 步骤更简单，无需有机溶剂
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
- 优异的扩增效率、可重复性和稳定性
- 卓越的灵敏度和准确性，操作简单
- 优化的缓冲液和T7 RNA聚合酶混合物
- 20 μL反应体系可获得更高的RNA产量
产品描述
Lasalocid is an ionophore antibiotic.
Lasalocid is produced by Streptomyces lasaliensis and is a mixture of several closely related homologue substances A, B, C, D, E. The sum of the lasalocid homologues B, C, D, E is limited to 10% of the total weight of the active substance, lasalocid.
In vitro: A previous study was conducted to compare effects of the combined use of lasalocid and silybin in chicken hepatoma cells and rat myoblasts cell lines cultures. Results showed that in all performed tests, the lowest lasalocid EC50-values were obtained for chicken hepatocytes. In the rat myoblasts cultures, the lowest lasalocid EC50-values were found. Moreover, a lack of silybin cytotoxic effect was proven for the studied cell lines. An interaction between both substances resulted in a great decrease of lasalocid cytotoxicity. The isobolograms and combination index indicated a significant antagonistic nature of silybin effect in the course of lasalocid cytotoxicity [1].
In vivo: In a animal study, chickens 8 or 9 days old were given a completely purified crystalline amino acid diet. Results showed that the requirement for sulphur-containing amino acids (SAA) was neither increased nor decreased by lasalocid at 125 mg/kg diet. Moreover, lasalocid could cause a significant increase in gain and gain/feed intake when added to diets that were deficient in SAA, but it led to a marked decrease in performance when added to diets adequate in SAA. In addition, at moderate levels of SAA deficiency, lasalocid at 125 mg/kg could neither increase nor decrease the rate and efficiency of weight gain and there was no evidence of the SAA X lasalocid interaction when lasalocid was given in a typical starter diet of maize and soya [2].
Clinical trial: So far, no clinical study has been conducted.
References:
[1] Radko, L. ,Cybulski, W., and Rzeski, W. The protective effect of silybin against lasalocid cytotoxic exposure on chicken and rat cell lines. Biomed.Res.Int. 2013, 1-8 (2013).
[2] Willis GM, Baker DH. Lasalocid-sulfur amino acid interrelationship in the chick. Poult Sci. 1980 Nov;59(11):2538-43.
产品性质
| 物理外观 | A solid |
| CAS号 | 25999-31-9 |
| 分子式 | C34H54O8 |
| 分子量 | 590.8 |
| 化学名称 | 6-[(3R,4S,5S,7R)-7-[(2S,3S,5S)-5-ethyl-5-[(2R,5R,6S)-5-ethyltetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yl]tetrahydro-3-methyl-2-furanyl]-4-hydroxy-3,5-dimethyl-6-oxononyl]-2-hydroxy-3-methyl-benzoic acid |
| 溶解度 | Soluble in ethanol;methanol;DMSO;dimethyl formamide |
| SMILES | OC(C1=C(CC[C@@H](C)[C@H](O)[C@H](C)C([C@@H]([C@]2([H])[C@@H](C)C[C@]([C@]3([H])O[C@@H](C)[C@@](O)(CC)CC3)(CC)O2)CC)=O)C=CC(C)=C1O)=O |
| 存储条件 | -20°C |
| 运输条件 | 蓝冰 |
产品应用 (实验数据来自文献，APExBIO并未验证，仅供参考)
IC50和靶点
| 生物活性描述 | Lasalocid （Lasalocid-A； Ionophore X-537A； Antibiotic X-537A）是一种用于饲料添加剂的抗菌和抗球虫剂。 |
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