JMS-17-2
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
JMS-17-2 是一种有效的选择性CX3CR1 小分子拮抗剂 (IC50: 0.32 nM)。 它能削弱乳腺癌细胞的转移和定植。 CX3CR1 是 CX3C 趋化因子 fractalkine (CX3CL1) 的受体。 研究表明，趋化因子受体 CX3CR1 能驱动癌细胞进入骨骼，激活正常细胞和癌细胞中的促生存信号通路，促进细胞存活。JMS-17-2对暴露于50nM Fractalkine的SKBR3乳腺癌细胞的ERK磷酸化，能产生剂量依赖性抑制。 SCID 小鼠移植了 MDA-231 细胞，并在 IC 注射后的第一周随机分配并给予载体或 10mg/Kg 的JMS-17-2 腹腔注射，每天两次，持续三周。 结果表明，它既能防止循环肿瘤细胞转化为播散性肿瘤细胞，又能抑制骨骼和内脏器官现有肿瘤数量和大小的扩大。
1. Shen F, et al. Novel Small-Molecule CX3CR1 Antagonist Impairs Metastatic Seeding and Colonization of Breast Cancer Cells. Mol Cancer Res. 2016 Jun;14(6):518-27.
| Storage | Store at -20°C |
| M.Wt | 419.95 |
| Cas No. | 1380392-05-1 |
| Formula | C25H26ClN3O |
| Solubility | ≥14.63 mg/mL in DMSO with ultrasonic |
| Chemical Name | 5-(3-(4-(4-chlorophenyl)piperidin-1-yl)propyl)pyrrolo[1,2-a]quinoxalin-4(5H)-one |
| SDF | Download SDF |
| Canonical SMILES | O=C1C2=CC=CN2C3=C(N1CCCN4CCC(CC4)C5=CC=C(Cl)C=C5)C=CC=C3 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
