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GN25

 
Catalog No.
C4840
p53-Snail结合抑制剂
组合的产品项目
规格价格库存 数量
10mg
¥ 1,245.00
Ship with 10-15 days
25mg
¥ 2,870.00
Ship with 10-15 days
50mg
¥ 3,954.00
Ship with 10-15 days

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A

背景

GN25 is a novel inhibitor of Snail-p53 binding [1].

P53 is a tumor suppressor that induces cell death, growth arrest and suppresses metastasis, and is often mutated or suppressed by various kinds of cellular signaling pathways in human cancers. In K-Ras-activated cancer cells, oncogenic K-Ras inhibits the p53 function through induction of Snail, which binds to and eliminates p53 through exocytosis. The specific inhibitor against p53-Snail binding would be used as anticancer drug against K-Ras-mutated or Snail-overexpressed cancers such as colon, pancreatic and lung cancers [1].

GN25 is a novel and specific inhibitor of Snail-p53 binding. GN25 is a 2-thio-dimethoxy naphthoquinone analog that induces p53 and p21 expression, and blocks the p53-Snail binding. In K-Ras-transformed mouse embryonic fibroblast (MEF), GN25 induced p53 and p21 in K-Ras-dependent way. In assay with capan-1 extract, GN25 significantly reduced interaction between p53 and Snail [1].

In nude mice inoculated A549 cells through i.p. injection, GN25 blocked the tumor progression and also induced tumor regression [1].

Reference:
[1].  Lee SH, Shen GN, Jung YS, et al. Antitumor effect of novel small chemical inhibitors of Snail-p53 binding in K-Ras-mutated cancer cells. Oncogene. 2010 Aug 12;29(32):4576-87.

文献引用

化学属性

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt322.3
Cas No.1227401-27-5
FormulaC15H14O6S
Solubility≤0.25mg/ml in ethanol;5mg/ml in DMSO;10mg/ml in dimethyl formamide
Chemical Name3-[(1,4-dihydro-5,8-dimethoxy-1,4-dioxo-2-naphthalenyl)thio]-propanoic acid
SDFDownload SDF
Canonical SMILESO=C1C=C(SCCC(O)=O)C(C2=C(OC)C=CC(OC)=C21)=O
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质量控制

质量控制和MSDS

批次:

化学结构

GN25

相关生物数据

GN25