Glatiramer acetate
| 规格 | 价格 | 货期 | 数量 |
|---|---|---|---|
| 5mg | ￥818.00 | 现货 | |
| 25mg | ￥2545.00 | 现货 |
特色产品
- 适用于流式细胞仪和荧光显微镜检测
- 准确区分活细胞/凋亡细胞/坏死细胞
- 用于免疫印迹和质谱分析等后续操作
- 适用于30 KDa-130 KDa大小的蛋白
- 对细胞无毒性
- 步骤更简单，无需有机溶剂
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
- 优异的扩增效率、可重复性和稳定性
- 卓越的灵敏度和准确性，操作简单
- 优化的缓冲液和T7 RNA聚合酶混合物
- 20 μL反应体系可获得更高的RNA产量
产品描述
Glatiramer acetate (GA) is a selective inhibitor of cytokine production by immature DC [1].
IL-12p70 is a key factor secreted by sentinel DC driving Th1 responses. The chronic activation of Th1 cells results in immunopathology and organ-specific autoimmune disease.
GA selectively inhibits cytokine produced by tissue-type sentinel DC. Different increasing dose of GA is added to the immature DC activated by exposure to LPS in vitro. The secretion of IL-12p70 was inhibited by GA in a dose-dependent manner. The mature DC in the presence of GA can induce Th2 cells accompanied by high levels of IL-10, which prime DC for reduced IL-12p70 production [1].
Applying GA to mice of three stages of experimental autoimmune encephalomyelitis by 8 to 10 days (2 mg per mouse) showed the expression of BDNF, NT-3 and NT-4 are continuously increasing in specific brain regions. Even started 45 days after disease induction, GA treatment restored the level of NTs back to that of healthy mice [2].
Reference:
[1] Wormmeester J, Vieira PL, Wierenga EA, et al. Glatiramer acetate (copolymer-1, Copaxone) promotes Th2 cell development and increased IL-10 production through modulation of dendritic cells. [J]. The Journal of Immunology: Official Journal of the American Association of Immunologists, 2003, 170(9): 4483-4488.
[2] Eilam R, Aharoni R, Arnon R, et al. The immunomodulator glatiramer acetate augments the expression of neurotrophic factors in brains of experimental autoimmune encephalomyelitis mice. [J]. Proceedings of the National Academy of Sciences of the United States of America. , 2005, 102(52): 19045-19050.
产品性质
| 物理外观 | A solid |
| CAS号 | 147245-92-9 |
| 分子式 | C25H45N5O13 |
| 分子量 | 623.65 |
| 化学名称 | (S)-2,6-diaminohexanoic acid compound with (S)-2-amino-3-(4-hydroxyphenyl)propanoic acid and (S)-2-aminopentanedioic acid and (S)-2-aminopropanoic acid and acetic acid (1:1:1:1:1) |
| 溶解度 | insoluble in EtOH; insoluble in DMSO; ≥65 mg/mL in H2O |
| SMILES | OC([C@@H](N)CC1=CC=C(O)C=C1)=O.CC(O)=O.OC([C@@H](N)C)=O.OC(CC[C@H](N)C(O)=O)=O.OC([C@@H](N)CCCCN)=O |
| 存储条件 | -20°C |
| 运输条件 | 蓝冰 |
产品应用 (实验数据来自文献，APExBIO并未验证，仅供参考)
IC50和靶点
| 生物活性描述 | 醋酸格拉替雷是一种人工合成的髓鞘碱性蛋白类似物，也是一种免疫调节剂，可用于多发性硬化症的研究。醋酸格拉替雷与 MHC 分子的结合力强且杂乱无章，因此会与各种髓鞘抗原竞争，使其呈现给 T 细胞。醋酸格拉替雷的另一个作用是强力诱导 T 辅助细胞 2（Th2）型的特异性抑制细胞迁移到大脑，导致原位旁观者抑制。 |
APExBIO 顾客使用本产品发表的 3 篇科研文献
- 1. nianqiang jin, Binhang Wang, et al. "Mannose-Doped Metal-Organic Frameworks Induce Tumor Cell Pyroptosis Via the PERK Pathway." Research Square. 15 Nov, 2023
- 2. Daming Wu, Xiao Zhao, et al. "Construction of a pH-responsive nanoreactor and its specific inhibition of oral squamous cell carcinoma growth via TME and xCT/GSH/GPX4 axis." Research Square. 18 Oct, 2023
- 3. Berke Karaahmet, John A Olschowka, et al. "Inconsistent Effects of Glatiramer Acetate Treatment in the 5xFAD Mouse Model of Alzheimer's Disease." Pharmaceutics. 2023 Jun 24;15(7):1809. PMID: 37513996
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