(-)-epicatechin gallate
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
(-)-epicatechin gallate是绿茶中主要的儿茶素成分[1]。
(-)-epicatechin gallate(ECG)在细胞生长抑制、细胞凋亡和膜转运系统中具有重要作用[1]。
(-)-epicatechin gallate是一种儿茶素。在HCT-116细胞中,ECG激活转录因子3(ATF3),其在促凋亡中发挥关键作用。EGR-1参与ECG诱导的ATF3的表达。在HCT-116细胞中,ECG(50 μM)以时间和剂量依赖的方式增加NAG-1和ATF3的表达。在HSC-2癌细胞中,ECG(50 μM)具有细胞毒性,NR50(midpoint cytotoxicity)值为67 μM。ECG(250 μM)诱导核小体DNA片段化和细胞凋亡。ECG(150 μM)显著增加caspase-3的活性[2]。然而,在正常HGF-2成纤维细胞中,ECG在浓度达到25 μM时才具有细胞毒性,NR50值为100 μM。
在大鼠中,ECG有五种代谢物,分别是(-)-epicatechin gallate、3’,4’’-di-O-methyl-(-)-epicatechin gallate、4’’-O-methyl-(-)-epicatechin gallate、4’-O-methyl-(-)-epicatechin gallate 和3’-O-methyl-(-)-epicatechin gallate,他们均随尿排出[3]。
参考文献:
[1]. Cho KN, Sukhthankar M, Lee SH, et al. Green tea catechin (-)-epicatechin gallate induces tumour suppressor protein ATF3 via EGR-1 activation. Eur J Cancer, 2007, 43(16): 2404-2412.
[2]. Babich H, Krupka ME, Nissim HA, et al. Differential in vitro cytotoxicity of (-)-epicatechin gallate (ECG) to cancer and normal cells from the human oral cavity. Toxicol In Vitro, 2005, 19(2): 231-242.
[3]. Kohri T, Suzuki M, Nanjo F. Identification of metabolites of (-)-epicatechin gallate and their metabolic fate in the rat. J Agric Food Chem, 2003, 51(18): 5561-5566.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 442.37 |
Cas No. | 1257-08-5 |
Formula | C22H18O10 |
Synonyms | ECG |
Solubility | ≥22.1 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH |
Chemical Name | (2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxychroman-3-yl 3,4,5-trihydroxybenzoate |
SDF | Download SDF |
Canonical SMILES | OC1=CC(C(O[C@@H]2CC3=C(C=C(O)C=C3O)O[C@@H]2C4=CC=C(O)C(O)=C4)=O)=CC(O)=C1O |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
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