Endothelin-1 (1-15), amide, human
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
内皮素是由内皮细胞产生的含有21个氨基酸的血管收缩肽,在血管稳态中发挥关键作用。内皮素-1是内皮素的一个亚型,内皮素含有ET-1、ET-2和ET-3三种亚型,具有不同的表达区域,至少与四种已知内皮素受体结合,即ETA、ETB1、ETB2和ETC[1]。
内皮素收缩血管和升高血压,它们通过其它机制保持平衡状态,但是,当它们过表达时,它们可以引起高血压和心脏疾病。
内皮素是已知的最有效的血管收缩剂[2]。在健康的个体中,由内皮素、其它血管收缩剂、一氧化氮、前列腺素以及其它血管扩张剂共同作用保持血管收缩和血管舒张之间的微妙平衡。内皮素多肽与受体在体内广泛分布,参与机体内各种生理和病理过程。内皮素失调可能引起许多疾病,例如几种类型的癌症、下蛛网膜下腔出血导致的血管痉挛、动脉高血压和其他心血管疾病、疼痛调节以及II型糖尿病等[3]。
Fig. 1: Formula of Endothelin-1, human
Fig. 2: Structure of Endothelin-1, human
参考文献:
1. Medical physiology a cellular and molecular approach (2nd ed., International ed. ed.). Philadelphia, PA: Saunders/Elsevier. 2009. pp. 480.
2. Modern pharmacology with clinical applications (6th ed. ed.). Philadelphia: Lippincott Williams & Wilkins. 2004. pp. 215.
3. Bagnato A, Rosanò L (2008). "The endothelin axis in cancer". Int. J. Biochem. Cell Biol. 40 (8): 1443–51.
Storage | Store at -20°C |
M.Wt | 1717.04 |
Formula | C70H109N17O23S5 |
Synonyms | H2N-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-NH2 |
Solubility | Soluble in water or 1% acetic acid |
SDF | Download SDF |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |