Dofequidar fumarate
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Dofequidar fumarate是多药耐药(MDR)逆转剂[1].
Dofequidar fumarate是一种喹啉衍生物,对多药耐药肿瘤细胞具有高度有效的逆转作用.Dofequidar fumarate可以直接作用于药物外排泵P-糖蛋白,防止抗肿瘤药物排出细胞,从而逆转多药耐药性.在耐长春新碱(VCR)P388/VCR细胞和耐阿霉素(ADM)P388/ADM细胞中,1 μM和3 μM Dofequidar fumarate能够完全逆转耐药性.Dofequidar fumarate对多药耐药性K562细胞也有显著作用.此外,在HCT-15细胞异种移植小鼠模型中,Dofequidar fumarate和Docetaxel联合治疗可以显著抑制肿瘤生长.Dofequidar fumarate对MCF-7/ADM耐药细胞荷瘤小鼠具有显著逆转作用[1,2].
参考文献：
[1] Sato W, Fukazawa N, Nakanishi O, et al. Reversal of multidrug resistance by a novel quinoline derivative, MS-209. Cancer chemotherapy and pharmacology, 1995, 35(4): 271-277.
[2] Naito M, Matsuba Y, Sato S, et al. MS-209, a quinoline-type reversal agent, potentiates antitumor efficacy of docetaxel in multidrug-resistant solid tumor xenograft models. Clinical cancer research, 2002, 8(2): 582-588.
| Storage | Store at -20°C |
| M.Wt | 597.66 |
| Cas No. | 153653-30-6 |
| Formula | C34H35N3O7 |
| Solubility | Soluble in DMSO |
| Chemical Name | 1-(4-(2-hydroxy-3-(quinolin-5-yloxy)propyl)piperazin-1-yl)-2,2-diphenylethanone fumarate |
| SDF | Download SDF |
| Canonical SMILES | OC(COC1=CC=CC2=C1C=CC=N2)CN3CCN(C(C(C4=CC=CC=C4)C5=CC=CC=C5)=O)CC3.O=C(O)/C([H])=C([H])/C(O)=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
化学结构
