BIO 1211
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
BIO 1211是一种选择性的和高亲和性的α4β1抑制剂，IC50值为0.004 μM [1]。
白细胞整合素α4β1介导白细胞募集、活化、凋亡抑制和介质释放，在炎症反应中起重要作用[1]。
BIO-1211对活化形式的α4β1的选择性约为200倍，刺激配体诱导的表位在整合素β1亚基上的表达，与占用受体的配体结合位点一致[1]。在Jurkat细胞中，BIO1211与无活性状态的整合素结合的KD值为20-40 nM，而与活性状态的整合素结合的KD值为100 pM。不同的KD值是由整合素-BIO1211复合体解离速率的不同所决定的[2]。
在过敏性羊中，BIO-1211以3 mg的雾化吸入剂量给药后防止carbachol诱导的非特异性气道高反应，抑制抗原挑战后引起的早期和晚期气道反应[1]。
参考文献：
[1]. Lin Kc, Ateeq HS, Hsiung SH, et al. Selective, tight-binding inhibitors of integrin α4β1 that inhibit allergic airway responses. J Med Chem, 1999, 42(5): 920-934.
[2]. Chen LL, Whitty A, Lobb RR, et al. Multiple activation sites of integrin α4β1 detected through their different affinities for a small molecule ligand. J Biol Chem, 1999, 274(19): 13167-13175.
| Physical Appearance | White lyophilised solid |
| Storage | Store at -20°C |
| M.Wt | 708.8 |
| Cas No. | 187735-94-0 |
| Formula | C36H48N6O9 |
| Solubility | Soluble to 2 mg/ml in 0.2M PBS |
| Chemical Name | (2S)-1-[(2S)-2-[[(2S)-3-carboxy-2-[[(2S)-4-methyl-2-[[2-[4-[(2-methylphenyl)carbamoylamino]phenyl]acetyl]amino]pentanoyl]amino]propanoyl]amino]-3-methylbutanoyl]pyrrolidine-2-carboxylic acid |
| SDF | Download SDF |
| Canonical SMILES | CC1=CC=CC=C1NC(=O)NC2=CC=C(C=C2)CC(=O)NC(CC(C)C)C(=O)NC(CC(=O)O)C(=O)NC(C(C)C)C(=O)N3CCCC3C(=O)O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
化学结构
