切换导航

Cyclo (-RGDfK)

Catalog No.
A8164
αvβ3整合素抑制剂
组合的产品项目
规格价格库存 数量
10mM (in 1mL DMSO)
¥ 1,500.00
现货
5mg
¥ 1,050.00
现货
25mg
¥ 3,350.00
现货
100mg
¥ 6,990.00
现货

电话: 021-55669583

邮箱: sales@apexbio.cn

全球经销商

Background

In one study where this peptide was labeled with 125I, it was found to bind specifically and with high affinity to αvβ3 receptors on neovascular blood vessel sections of different major human cancers. The integrin alpha(IIb)beta(3)-specific cyclic hexapeptide contains an Arg-Gly-Asp (RGD) sequence.

文献引用

1. Lee HN, Bosompra OA, Coller HA. "RECK isoforms differentially regulate fibroblast migration by modulating tubulin post-translational modifications." Biochem Biophys Res Commun. 2019 Mar 5;510(2):211-218. PMID:30704758
2. Lim C, Moon J, et al. "Cyclic RGD-conjugated Pluronic(®) blending system for active, targeted drug delivery." Int J Nanomedicine. 2018 Aug 10;13:4627-4639. PMID:30127610
3. Schneider G, Suszynska M, Kakar S, et al. "Vitronectin in the Ascites of Human Ovarian Carcinoma Acts as a Potent Chemoattractant for Ovarian Carcinoma: Implication for Metastasis by Cancer Stem Cells[J]." Journal of Cancer Stem Cell Research, 2016, 4: e1005.

Chemical Properties

StorageStore at -20°C
M.Wt603.7
Cas No.161552-03-0
FormulaC27H41N9O7
SynonymsCyclo(-Arg-Gly-Asp-D-Phe-Lys)
Solubility≥30.185mg/mL in DMSO,insoluble in EtOH, ≥59.2 mg/mL in H2O
Chemical Name2-[(2S,5R,8S,11S)-8-(4-aminobutyl)-5-benzyl-11-[3-(diaminomethylideneamino)propyl]-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid
SDFDownload SDF
Canonical SMILESC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCN=C(N)N)CCCCN)CC2=CC=CC=C2)CC(=O)O
运输条件试用装:蓝冰运输。 其他可选规格:常温运输或根据您的要求用蓝冰运输。
一般建议为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。

生物活性

Description Cyclo (-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin.
Targets Integrin          
IC50            

质量控制

化学结构

Cyclo (-RGDfK)

相关生物数据

Cyclo (-RGDfK)

相关生物数据

Cyclo (-RGDfK)

相关生物数据

Cyclo (-RGDfK)