AGN 192403 hydrochloride
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
AGN 192403 hydrochloride是一种选择性的咪唑啉1受体的配体[1].
咪唑啉受体是可乐定和其他咪唑啉的主要受体.咪唑啉1受体(I1受体)通过咪唑啉抑制交感神经行为,从而降低血压.
AGN 192403 hydrochloride是一种选择性的I1受体的配体.AGN192403表现出对I1受体的亲和力,Ki值为42 nM,比可乐定效力仅低5倍.然而,AGN192403没有激动剂和拮抗剂活性.在猴子和大鼠中,AGN192403(5000 μg/kg)对血压没有影响[1].在星形胶质细胞中,AGN 192403抑制细胞色素c释放\溶酶体吖啶橙再定位\caspase-9的激活和线粒体膜电位的降低\萘醌诱导的细胞毒性.此外,AGN 192403抑制抗霉素A\鱼藤酮和线粒体呼吸抑制剂诱导的线粒体功能障碍和细胞毒性[2].在离体正常血压大鼠心脏中,AGN192403抑制moxonidine(10-6 M)诱导的心房利钠肽(ANP)的释放[3].
参考文献：
[1] unk SA1, Lai RK, Burke JE,Munk SA1, Lai RK, Burke JE,Synthesis and pharmacologic evaluation of 2-endo-amino-3-exo-isopropylbicyclo[2. 2.1]heptane: a potent imidazoline1 receptor specific agent.Munk et al (1996) Synthesis and pharmacologic evaluation of 2-endo-amino-3-exo-isopropylbicyclo[2.2.1]heptane: a potent imidazoline1 receptor specific agent. J.Med.Chem. 39 1193. PMID: 8632424.Stephen A. Munk,* Ronald K. Lai, James E. Burke, [1]. Munk SA, Lai RK, Burke JE, et al. Synthesis and Pharmacologic Evaluation of 2-endo-Amino-3-exoisopropylbicyclo[2.2.1]heptane: A Potent Imidazoline1 Receptor Specific Agent. J Med Chem, 1996, 39(6): 1193-1195.
[2]. Choi DH, Kim DH, Park YG, et al. Protective effects of rilmenidine and AGN 192403 on oxidative cytotoxicity and mitochondrial inhibitor-induced cytotoxicity in astrocytes. Free Radic Biol Med, 2002, 33(10): 1321-1333.
[3]. Mukaddam-Daher S, Menaouar A, Gutkowska J. Receptors involved in moxonidine-stimulated atrial natriuretic peptide release from isolated normotensive rat hearts. Eur J Pharmacol, 2006, 541(1-2): 73-79.
| Physical Appearance | White solid |
| Storage | Store at RT |
| M.Wt | 189.73 |
| Cas No. | 1021868-90-5 |
| Formula | C10H19N·HCl |
| Solubility | Soluble to 100 mM in H2O |
| Chemical Name | (1R,2R,3R,4S)-3-isopropylbicyclo[2.2.1]heptan-2-amine hydrochloride |
| SDF | Download SDF |
| Canonical SMILES | CC([C@]1([H])[C@@]2([H])CC[C@]([C@@]1([H])N)([H])C2)C.Cl |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
化学结构
