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6-OAU

 
Catalog No.
C5367
GPR84的合成激动剂
组合的产品项目
规格价格库存 数量
1mg
¥ 1,090.00
Ship with 10-15 days
5mg
¥ 3,818.00
Ship with 10-15 days
10mg
¥ 5,454.00
Ship with 10-15 days

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A

背景

6-OAU is a synthetic agonist for GPR84.

GPR84, a Gαi protein-coupled receptor, is activated by medium-chain free fatty acids, but only at micromolar concentrations. GPR84 is also a putative receptor for medium-chain fatty acids. GPR84 is expressed in leukocytes and its expression can be further induced by LPS.

In vitro: A previous study identified 6-OAU as a surrogate agonist for GPR84. It was found that 6-OAU and potential ligands were able to stimulate [(35)S]GTP binding and accumulate phosphoinositides in a GPR84-dependent manner. Moreover, 6-OAU could internalize GPR84-EGFP from the cell surface. In addition, results showed that both 6-OAU and the potential ligands could elicite chemotaxis of human polymorphonuclear leukocytes (PMNs) and macrophages and amplify LPS-stimulated production of the proinflammatory cytokine IL-8 from PMNs and TNFα from macrophages [1].

In vivo: Animal study found that the iv injection of 6-OAU was able to raise the blood CXCL1 level in rats. In addition, the inoculation of 6-OAU into the rat air pouch could accumulate PMNs and macrophages in the site [1].

Clinical trial: So far, no clinical study has been conducted.

Reference:
[1] Suzuki, M. ,Takaishi, S.,Nagasaki, M., et al. Medium-chain fatty acid-sensing receptor, GPR84, is a proinflammatory receptor. The Journal of Biological Chemisty 288(15), 10684-10691 (2013).

化学属性

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt239.3
Cas No.83797-69-7
FormulaC12H21N3O2
Solubility≤0.25mg/ml in DMSO;0.25mg/ml in dimethyl formamide
Chemical Name6-(octylamino)-2,4(1H,3H)-pyrimidinedione
SDFDownload SDF
Canonical SMILESO=C1NC(NCCCCCCCC)=CC(N1)=O
运输条件 蓝冰运输或根据您的需求运输。
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质量控制

质量控制和MSDS

批次:

化学结构

6-OAU