2-Imino-4-methylpiperidine (acetate)
| 规格 | 价格 | 货期 | 数量 |
|---|---|---|---|
| 10mg | ￥1300.00 | 10-15工作日发货 | |
| 25mg | ￥2816.00 | 10-15工作日发货 | |
| 50mg | ￥3466.00 | 10-15工作日发货 |
特色产品
- 适用于流式细胞仪和荧光显微镜检测
- 准确区分活细胞/凋亡细胞/坏死细胞
- 用于免疫印迹和质谱分析等后续操作
- 适用于30 KDa-130 KDa大小的蛋白
- 对细胞无毒性
- 步骤更简单，无需有机溶剂
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
- 优异的扩增效率、可重复性和稳定性
- 卓越的灵敏度和准确性，操作简单
- 优化的缓冲液和T7 RNA聚合酶混合物
- 20 μL反应体系可获得更高的RNA产量
产品描述
2-Imino-4-methylpiperidine (acetate) is a potent NOS inhibitor [1]
Nitric oxide (NO) is an endogenously produced inorganic free radical gas which has been implicated in endothelium-dependent vascular relaxation, cell-to-cell communication, and cytotoxicity associated with phagocytic cells. NO is synthesized by three isoforms of nitric oxide synthase (NOS): nNOS, eNOS and iNOS [1].
2-Imino-4-methylpiperidine (acetate) is a 2-iminopiperidine class of NOS inhibitor. In the presence of a final L-arginine concentration of 30 μM, 2-Imino-4-methylpiperidine inhibited human iNOS, eNOS, and nNOS with IC50 values of 0.1, 1.1, and 0.2 μM, respectively. 2-Imino-4-methylpiperidine exhibited 9-fold and 1-fold selectivity for iNOS compared to eNOS and nNOS, respectively [1].
In LPS-treated rats, 2-Imino-4-methylpiperidine (10 mg/kg, po) inhibited plasma nitrite levels by 87%.
Reference:
[1]. Webber RK, Metz S, Moore WM, et al. Substituted 2-iminopiperidines as inhibitors of human nitric oxide synthase isoforms. J Med Chem. 1998 Jan 1;41(1):96-101.
产品性质
| 物理外观 | A crystalline solid |
| CAS号 | 165383-72-2 |
| 分子式 | C6H12N2 · C2H3O2 |
| 分子量 | 171.2 |
| 小分子别名 | NOS-IN-1 |
| 化学名称 | 3,4,5,6-tetrahydro-4-methyl-2-pyridinamine, acetate |
| 溶解度 | ≤5mg/ml in ethanol;5mg/ml in DMSO;5mg/ml in dimethyl formamide |
| SMILES | CC1CCN=C(N)C1.CC([O-])=O |
| 存储条件 | -20°C |
| 运输条件 | 蓝冰 |
产品应用 (实验数据来自文献，APExBIO并未验证，仅供参考)
IC50和靶点
| 生物活性描述 | NOS-IN-1 是一种强效口服活性 NO 合酶（NOS）异构体抑制剂，对人类 iNOS（hiNOS）、heNOS 和 hnNOS 的 IC50 分别为 0.1 μM、1.1 μM 和 0.2 μM。 |
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