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Sodium molybdate

 
Catalog No.
B7843
酸性和磷蛋白磷酸酶抑制剂
组合的产品项目
规格价格库存 数量
5g
¥ 454.00
现货
10g
¥ 727.00
现货

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A

背景

Sodium molybdate is an acid phosphatase inhibitor. The osteoclastic acid phosphatase isoenzyme, secreted by osteoclasts, is a member of a widely-distributed class of iron-containing proteins with acid phosphatase activity. Elevated plasma isoenzyme levels are associated with increased bone turnover in metabolic disease. By inhibiting this class of acid phosphatases, sodium molybdate is capable of abolishing bone resorption. In addition, sodium molybdate has been shown to stabilize the nonactivated glucocorticoid-receptor complex.

References:

1. Zaidi M, Moonga B, Moss DW, et al. Inhibition of osteoclastic acid phosphatase abolishes bone resorption. Biochemical and Biophysical Research Communications, 1989, 159(1): 68-71.

2. Denis M, Wikström AC, Gustafsson JA. The molybdate-stabilized nonactivated glucocorticoid receptor contains a dimer of Mr 90,000 non-hormone-binding protein. Journal of Biological Chemistry, 1987, 262(24): 11803-11806.

化学属性

Physical AppearanceA solid
StorageStore at -20°C
M.Wt205.94
Cas No.7631-95-0
FormulaMoNa2O4
Solubilityinsoluble in EtOH; insoluble in DMSO; ≥20.6 mg/mL in H2O
Chemical Namesodium molybdate
SDFDownload SDF
Canonical SMILES[O-][Mo](=O)([O-])=O.[Na+].[Na+]
运输条件 蓝冰运输或根据您的需求运输。
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试验操作

Cell experiment:[1]

Cell lines

Rat osteoclasts

Reaction Conditions

1 ~ 100 μM sodium molybdate

Applications

Addition of the phosphatase inhibitor sodium molybdate to the bone-osteoclast cultures at a concentration of 100 μM abolished bone resorption and reduced tartrate-resistant acid phosphatase activity by about 40%.

Note

The technical data provided above is for reference only.

References:

1. Zaidi M, Moonga B, Moss DW, et al. Inhibition of osteoclastic acid phosphatase abolishes bone resorption. Biochemical and Biophysical Research Communications, 1989, 159(1): 68-71.

2. Denis M, Wikström AC, Gustafsson JA. The molybdate-stabilized nonactivated glucocorticoid receptor contains a dimer of Mr 90,000 non-hormone-binding protein. Journal of Biological Chemistry, 1987, 262(24): 11803-11806.

质量控制

质量控制和MSDS

批次:

化学结构

a'Sodium