Caspase - Irreversible
Caspases (cysteine-dependent aspartate specific ptotease) are a family of cysteine proteases that play an essential role in cell apoptosis. Caspases contain a conserved QACXG pentapeptide active site motif and are characterized by specificity for aspartic acid in the P1 position. The synthesis of caspases involves the activation of inactive proenzymes, which contain an N-terminal peptide (prodomain) together with two subunits (one small and one large), following cleavage at specific aspartate cleavage sites. Caspases can be classified into three subfamilies, due to phylogenetic analysis, including an ICE subfamily (caspases-1, -4 and -5), a CED-3/CPP32 subfamily (caspases-3, -6, -7, -8, -9 and -10) and an ICH-1/Nedd2 subfamily (caspase-2).
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- A8170 Z-FA-FMKTarget: cysteine proteaseSummary: 半胱氨酸蛋白酶抑制剂
- B3233 Z-LEHD-FMK8 CitationTarget: CaspasesSummary: 不可逆的Caspase-9抑制剂
- B3232 Z-IETD-FMK12 CitationTarget: CaspasesSummary: Caspase-8抑制剂
- A1923 Z-VEID-FMK2 CitationTarget: CaspasesSummary: Caspase-6抑制剂
- A1921 Z-DQMD-FMK3 CitationTarget: CaspasesSummary: 细胞渗透性Caspase-3抑制剂
- A1920 Z-DEVD-FMK12 CitationTarget: CaspasesSummary: Caspase-3抑制剂
- A1904 Boc-D-FMK1 CitationTarget: CaspasesSummary: 广谱caspase抑制剂
- A1901 Q-VD-OPh53 CitationTarget: CaspasesSummary: Pan-caspase抑制剂。