Siramesine
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Siramesine(Lu 28-179)是一种特异性的σ受体激动剂[1].
在人皮质与大鼠脑匀浆中,Siramesine(Lu 28-179)特异性地结合σ2受体,其Kd值分别为1.1 ± 0.2 nM和2.2 ± 0.4 nM,最大结合容量Bmax值分别为26 ± 3 fmol mg tissue-1和50 ± 12 fmol mg tissue-1.[3H]Lu28-179选择性地结合大鼠与人脑膜,相应Ki值为4.4 ± 1.7 nM和8.6 ± 0.6 nM.此外,Siramesine以极高的亲和力取代了[3H] DTG结合,并取代了结合于σ2位点的[3H](+)pentazocine.Siramesine抑制[3H]DTG结合的IC50值为0.19 nM[1].
参考文献：
[1] Sby KK1, Mikkelsen JD, Meier E, Thomsen C. Lu 28-179 labels a sigma(2)-site in rat and human brain. Neuropharmacology. 2002 Jul;43(1):95-100.
| Storage | Store at -20°C |
| M.Wt | 454.58 |
| Cas No. | 147817-50-3 |
| Formula | C30H31FN2O |
| Solubility | Soluble in DMSO |
| Chemical Name | 1'-[4-[1-(4-fluorophenyl)indol-3-yl]butyl]spiro[1H-2-benzofuran-3,4'-piperidine] |
| SDF | Download SDF |
| Canonical SMILES | C1CN(CCC12C3=CC=CC=C3CO2)CCCCC4=CN(C5=CC=CC=C54)C6=CC=C(C=C6)F |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
化学结构
