Safinamide Mesylate
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Safinamide Mesylate是活性组分safinamide的甲磺酸形式，Safinamide是选择性和可逆的单胺氧化酶B（MAO-B）抑制剂，IC50值为98 nM。Safinamide可以用于治疗帕金森氏病（PD），多巴胺是MAO-B的底物，safinamide强效调节多巴胺（DA），抑制多巴胺吸收，Safinamide与MAO-B可逆地结合，阻碍MAO-B的功能，进而缓解PD症状。除了抑制MAO-B外，Safinamide还具有一定的抗惊厥效果，可以作为钠通道、钙通道阻滞剂，抑制谷氨酸的释放，其IC50分别值8.2 μM，31.5 μM和大于56.4 μM。
参考文献：
Fariello RG, McArthur RA, Bonsignori A, Cervini MA, Maj R, Marrari P, Pevarello P, Wolf HH, Woodhead JW, White HS, Varasi M, Salvati P, Post C. Preclinical evaluation of PNU-151774E as a novel anticonvulsant. J Pharmacol Exp Ther. 1998; 285(2): 397-403
Onofrj M, Bonanni L, Thomas A. An expert opinion on safinamide in Parkinson's disease. Expert Opin Investig Drugs. 2008;17(7):1115-1125
Naveed M Malek, Donald G Grosset. Investigational agents in the treatment of Parkinson's disease: focus on safinamide. Journal of Experimental Pharmacology 2012: 4 85-90
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 398.45 |
| Cas No. | 202825-46-5 |
| Formula | C17H19FN2O2·CH4O3S |
| Synonyms | FCE-28073, PNU 151774E, methanesulfonate |
| Solubility | ≥10.08 mg/mL in EtOH with gentle warming and ultrasonic; ≥16.1 mg/mL in DMSO; ≥84.6 mg/mL in H2O |
| Chemical Name | (2S)-2-[[4-[(3-fluorophenyl)methoxy]phenyl]methylamino]propanamide;methanesulfonic acid |
| SDF | Download SDF |
| Canonical SMILES | CC(C(=O)N)NCC1=CC=C(C=C1)OCC2=CC(=CC=C2)F.CS(=O)(=O)O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
| Description | Safinamide Mesylate（沙芬酰胺甲磺酸）是MAO-B的有效选择性抑制剂，IC50值为98 nM。 | |||||
| 靶点 | MAO-B | |||||
| IC50 | 98 nM | |||||
质量控制和MSDS
- 批次:
化学结构
