Rimeporide
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Rimeporide (EMD-87580)是一种有效的选择性Na+/H+交换剂 (NHE-1) 抑制剂[1]。Rimeporide 抑制NHE-1活性以减少细胞内Na+和Ca2+ 过载和pH值。Rimeporide是治疗杜氏肌营养不良的新选择[1]。Rimeporide完全消除了去氧肾上腺素引起的细胞肥大[2]。
参考文献:
[1]. F.Porte-Thomé, et al. Development of Rimeporide, a sodium-hydrogen exchanger (NHE-1) inhibitor, for patients with Duchenne muscular dystrophy. Neuromuscular Disorders. October 2015 Oct 25:259-260.
[2]. Stanbouly S, et al. Sodium hydrogen exchange 1 (NHE-1) regulates connexin 43 expression in cardiomyocytes via reverse mode sodium calcium exchange and c-Jun NH2-terminal kinase-dependent pathways. J Pharmacol Exp Ther. 2008 Oct;327(1):105-13. PMID: 18650245
Storage | Store at -20°C |
M.Wt | 333.38 |
Cas No. | 187870-78-6 |
Formula | C11H15N3O5S2 |
Synonyms | EMD-87580 |
Solubility | ≥35.1 mg/mL in DMSO |
Chemical Name | N-carbamimidoyl-2-methyl-4,5-bis(methylsulfonyl)benzamide |
SDF | Download SDF |
Canonical SMILES | O=C(C1=CC(S(=O)(C)=O)=C(C=C1C)S(=O)(C)=O)NC(N)=N |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
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