Prochlorperazine
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 373.94 |
| Cas No. | 58-38-8 |
| Formula | C20H24ClN3S |
| Solubility | insoluble in H2O; ≥16.5 mg/mL in DMSO; ≥58.5 mg/mL in EtOH |
| Chemical Name | 2-chloro-10-(3-(4-methylpiperazin-1-yl)propyl)-10H-phenothiazine |
| SDF | Download SDF |
| Canonical SMILES | CN(CC1)CCN1CCCN2C3=CC=CC=C3SC4=C2C=C(Cl)C=C4 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
| Cell experiment:[1] | |
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Cell lines |
BT474 cells |
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Reaction Conditions |
5 μM prochlorperazine for 2 or 5 d incubation |
|
Applications |
In BT474 cells that over-express HER2 and have previously been shown to be tamoxifen resistant, treatment with 5 μM of prochlorperazine in the presence or absence of 4-hydroxytamoxifen significantly inhibited cell proliferation and reduced cyclin E2 mRNA levels. Prochlorperazine has the potential to inhibit proliferation of tamoxifen-resistant breast tumors. |
| Animal experiment:[2] | |
|
Animal models |
Beagle dogs, 8 ~ 16 kg |
|
Dosage form |
0.34 mg/kg Administered subcutaneously |
|
Applications |
Prochlorperazine inhibited emesis induced by apomorphine in dogs, with an ED50 value of 0.34 mg/kg. |
|
Note |
The technical data provided above is for reference only. |
|
References: 1. Huang L, Zhao S, Frasor JM, et al. An integrated bioinformatics approach identifies elevated cyclin E2 expression and E2F activity as distinct features of tamoxifen resistant breast tumors. PLoS One, 2011, 6(7): e22274. 2. Niemegeers CJ. Antiemetic specificity of dopamine antagonists. Psychopharmacology (Berl), 1982, 78(3): 210-213. |
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质量控制和MSDS
- 批次:
化学结构
