PD 144418 oxalate
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
PD 144418 oxalate is a highly potent and selective ligand of the sigma-1 (σ1) receptor, with Ki values being 0.08 and 1377 nM for σ1 and σ2 receptors, respectively. The σ1 receptor, one of two σ receptor subtypes, is a transmembrane protein widely expressed in a variety of tissues, and it is relatively concentrated in certain regions of the central nervous system. The σ receptor has been implicated in many neuronal processes, as well as in the pathophysiology of certain psychiatric disorders, including depression, schizophrenia, motor disturbances, pain, drug addiction, attention deficit disorders, and probably cancer.
References:
1. Akunne HC, Whetzel SZ, Wiley JN, et al. The pharmacology of the novel and selective sigma ligand, PD 144418. Neuropharmacology, 1997, 36(1): 51-62.
2. Guitart X, Codony X, Monroy X. Sigma receptors: biology and therapeutic potential. Psychopharmacology (Berl), 2004, 174(3): 301-319.
| Physical Appearance | Off-white solid |
| Storage | Desiccate at RT |
| M.Wt | 372.42 |
| Cas No. | 154130-99-1 |
| Formula | C18H22N2O·C2H2O4 |
| Solubility | <18.62mg/ml in DMSO |
| Chemical Name | 5-(1-propyl-1,2,5,6-tetrahydropyridin-3-yl)-3-(p-tolyl)isoxazole oxalate |
| SDF | Download SDF |
| Canonical SMILES | CCCN1CCC=C(C2=CC(C3=CC=C(C)C=C3)=NO2)C1.OC(C(O)=O)=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
| Animal experiment:[1] | |
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Animal models |
Male CD-1 mice |
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Dosage form |
3, 10 and 30 mg/kg Administered intraperitoneally 60 min before oral administration of mescaline HCl |
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Applications |
Similar to other σ ligands such as haloperidol and clozapine, PD 144418 was able to antagonize mescaline-induced scratching at doses that did not alter spontaneous motor activity, with an ED50 value of 7.0 mg/kg. |
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Note |
The technical data provided above is for reference only. |
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References: 1. Akunne HC, Whetzel SZ, Wiley JN, et al. The pharmacology of the novel and selective sigma ligand, PD 144418. Neuropharmacology, 1997, 36(1): 51-62. 2. Guitart X, Codony X, Monroy X. Sigma receptors: biology and therapeutic potential. Psychopharmacology (Berl), 2004, 174(3): 301-319. |
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质量控制和MSDS
- View current batch:
-
Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
化学结构
