Pargyline (hydrochloride)
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
IC50: 11.52 nM: inhibits monoamine oxidase (MAO) type A (MAO-A).
IC50: 8.2 nM: blocks MAO type B (MAO-B).
Pargyline, an irreversible and non-selective inhibitor of MAO, is used to treat moderate hypertension and cancer cells. There are two isoforms of MAO, MAO-A and MAO-B. MAO-A preferentially deaminates melatonin, serotonin, norepinephrine and epinephrine. MAO-B catalyzes the oxidative deamination and inactivation of certain catecholamines within the presynaptic nerve terminals.
In vitro: Pargyline reduced the proliferation of human prostate carcinoma (LNCaP-LN3) cells in a time- and dose-dependent fashion. In addition, compared to the control, pargyline remarkably triggered cell cycle arrest at the G1 phase. Pargyline elicited an increase in the cell death rate via promoting apoptosis, suggesting that pargyline was a powerful candidate drug for the treatment of human prostate cancer [1].
In vivo: Male rats were injected intraperitoneally pargyline at a dose of 75 mg/kg for 80 min. Pargyline significantly increased the concentration of extracellular dopamine in the striatum and simultaneously, significantly reduced the concentration of extracellular MAO-derived metabolite 3,4-dihydroxyphenylacetic acid to undetectable levels [2].
References:
[1]. Chai, Y. Effects of the monoamine oxidase inhibitors pargyline and tranylcypromine on cellular proliferation in human prostate cancer cells. Oncology Reports. 2013.
[2]. Desvignes, C., Bert, L., Vinet, L., Denoroy, L., Renaud, B., & Lambás-Seas, L. Evidence that the neuronal nitric oxide synthase inhibitor 7-nitroindazole inhibits monoamine oxidase in the rat: in vivo effects on extracellular striatal dopamine and 3,4-dihydroxyphenylacetic acid. Neuroscience Letters. 1999; 261(3):175-178.
Storage | Store at -20°C |
M.Wt | 195.7 |
Cas No. | 306-07-0 |
Formula | C11H13N·HCl |
Solubility | ≥33.55 mg/mL in EtOH; ≥51.6 mg/mL in H2O; ≥7.55 mg/mL in DMSO |
Chemical Name | N-methyl-N-2-propynyl-benzenemethanamine, monohydrochloride |
SDF | Download SDF |
Canonical SMILES | CN(CC#C)CC1=CC=CC=C1.Cl |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
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