Moclobemide (Ro 111163)
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Moclobemide是单胺氧化酶A(MAO-A)的可逆抑制剂,IC50值为10 μM[1]。
Moclobemide是RIMA试剂的原型,具有抗抑郁功效,对类似于高血压等致命性疾病的副作用风险较小。使用大鼠脑匀浆进行体外实验发现,Moclobemide 特异性抑制MAO-A,但抑制能力较弱。对MAO-A和MAO-B的IC50值分别为6 mM和1000 mM。在体外动物实验中,Moclobemide在脑和肝中产生80%的抑制性。此外,高剂量moclobemide的长期给药可以下调β肾上腺素能受体,增加α1肾上腺素受体激动剂结合的亲和力。此外,口服moclobemide几乎可以被迅速的完全吸收。单独给药100 mg moclobemide,生物利用度约为50%[2]。
参考文献:
[1] Pisani L, Barletta M, Soto-Otero R, Nicolotti O, Mendez-Alvarez E, Catto M, Introcaso A, Stefanachi A, Cellamare S, Altomare C, Carotti A. Discovery, biological evaluation, and structure-activity and -selectivity relationships of 6'-substituted (E)-2-(benzofuran-3(2H)-ylidene)-N-methylacetamides, a novel class of potent and selective monoamine oxidase inhibitors. J Med Chem. 2013 Mar 28;56(6):2651-64.
[2] Nair NP, Ahmed SK, Kin NM. Biochemistry and pharmacology of reversible inhibitors of MAO-A agents: focus on moclobemide. J Psychiatry Neurosci. 1993 Nov;18(5):214-25.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 268.74 |
Cas No. | 71320-77-9 |
Formula | C13H17ClN2O2 |
Solubility | insoluble in H2O; ≥48.3 mg/mL in EtOH with ultrasonic; ≥9.85 mg/mL in DMSO |
Chemical Name | 4-chloro-N-(2-morpholin-4-ylethyl)benzamide |
SDF | Download SDF |
Canonical SMILES | C1COCCN1CCNC(=O)C2=CC=C(C=C2)Cl |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
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