ML365
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
ML365 是一种选择性的双孔结构域钾通道TASK1/KCNK3抑制剂，其IC50值为4nM。ML365可作为药理学工具（探针），用于检查TASK1通道的特定作用。ML365在铊流入荧光测定(IC50 = 4 nM)和自动电生理学测定(IC50 = 16 nM)中均阻断TASK1通道。ML365在30 μM对更远亲的钾通道、Kir2.1、钾电压门控通道、KQT样亚家族成员2 (KCNQ2)和人类ether-a go-go相关基因(hERG )表现出很少或没有抑制[1]。
参考文献：
[1]. Zou B, Flaherty DP, Simpson DS, Maki BE, Miller MR, Shi J, Wu M, McManus OB, Golden JE, Aubé J, Li M. ML365: Development of Bis-Amides as Selective Inhibitors of the KCNK3/TASK1 Two Pore Potassium Channel. 2013 Apr 15 [updated 2013 Nov 14]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–. PMID: 24479195.
| Storage | Store at -20°C |
| M.Wt | 360.41 |
| Cas No. | 947914-18-3 |
| Formula | C22H20N2O3 |
| Solubility | ≥37 mg/mL in DMSO |
| Chemical Name | 2-methoxy-N-(3-(3-methylbenzamido)phenyl)benzamide |
| SDF | Download SDF |
| Canonical SMILES | O=C(C1=C(OC)C=CC=C1)NC2=CC=CC(NC(C3=CC=CC(C)=C3)=O)=C2 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
