Mesoridazine
| 规格 | 价格 | 货期 | 数量 |
|---|---|---|---|
| 1mL(10 mM in DMSO) | ￥454.00 | 现货 | |
| 10mg | ￥727.00 | 现货 | |
| 50mg | ￥2727.00 | 现货 |
特色产品
- 适用于流式细胞仪和荧光显微镜检测
- 准确区分活细胞/凋亡细胞/坏死细胞
- 用于免疫印迹和质谱分析等后续操作
- 适用于30 KDa-130 KDa大小的蛋白
- 对细胞无毒性
- 步骤更简单，无需有机溶剂
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
- 优异的扩增效率、可重复性和稳定性
- 卓越的灵敏度和准确性，操作简单
- 优化的缓冲液和T7 RNA聚合酶混合物
- 20 μL反应体系可获得更高的RNA产量
产品描述
Mesoridazine is a dopaminergic antagonist, with a Kd value of 19 nM for the dopamine D2 receptor. Mesoridazine is an active metabolite of the atypical antipsychotic drug thioridazine, exhibiting stronger inhibition on pre- and postsynaptic dopamine receptors which modulate dopamine and acetylcholine release. Thus, mesoridazine is responsible for a significant part of the antidopaminergic effects attributed to thioridazine. In addition, mesoridazine also binds to histamine H1, muscarinic acetylcholine, as well as α1- and α2-adrenergic receptors, with Kd values being 1.8, 69, 2 and 1600 nM, respectively.
References:
1. Niedzwiecki DM, Cubeddu LX, Mailman RB. Comparative antidopaminergic properties of thioridazine, mesoridazine and sulforidazine on the corpus striatum. Journal of Pharmacology and Experimental Therapeutics, 1989, 250(1): 117-125.
2. Richelson E, Nelson A. Antagonism by neuroleptics of neurotransmitter receptors of normal human brain in vitro. European Journal of Pharmacology, 1984, 103(3-4): 197-204.
3. Shah NS. Influence of psychotropic drugs and β-diethylaminoethyl-diphenylpropylacetate (SKF 525-A) on mescaline-induced behavior and on tissue levels of mescaline in mice. Biochemical Pharmacology, 1976, 25(5): 591-597.
产品性质
| 物理外观 | A solid |
| CAS号 | 5588-33-0 |
| 分子式 | C21H26N2OS2 |
| 分子量 | 386.57 |
| 化学名称 | 10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(methylsulfinyl)-10H-phenothiazine |
| 溶解度 | insoluble in H2O; ≥16.35 mg/mL in DMSO; ≥3.1 mg/mL in EtOH |
| SMILES | CN1C(CCN2c(cc(cc3)S(C)=O)c3Sc3c2cccc3)CCCC1 |
| 存储条件 | -20°C |
| 运输条件 | 蓝冰 |
产品应用 (实验数据来自文献，APExBIO并未验证，仅供参考)
IC50和靶点
| 生物活性描述 | 美索利达嗪（硫利达嗪 EP 杂质 B）是一种吩噻嗪类抗精神病药，作用与氯丙嗪相似。 |
质量控制
操作说明
APExBIO 顾客使用本产品发表的 1 篇科研文献
- 1. Peter Kilfoil, Shuyun Lily Feng, et al. "Characterization of a high throughput human stem cell cardiomyocyte assay to predict drug-induced changes in clinical electrocardiogram parameters." Eur J Pharmacol. 2021 Dec 5;912:174584. PMID: 34678241
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