LB-100
| 规格 | 价格 | 货期 | 数量 |
|---|---|---|---|
| 5mg | ￥954.00 | 现货 | |
| 25mg | ￥3045.00 | 现货 | |
| 100mg | ￥6354.00 | 现货 |
特色产品
- 适用于流式细胞仪和荧光显微镜检测
- 准确区分活细胞/凋亡细胞/坏死细胞
- 用于免疫印迹和质谱分析等后续操作
- 适用于30 KDa-130 KDa大小的蛋白
- 对细胞无毒性
- 步骤更简单，无需有机溶剂
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
- 优异的扩增效率、可重复性和稳定性
- 卓越的灵敏度和准确性，操作简单
- 优化的缓冲液和T7 RNA聚合酶混合物
- 20 μL反应体系可获得更高的RNA产量
产品描述
LB-100 is an inhibitor of protein phosphatase 2A (PP2A) with anticancer activity, with IC50 of 0.85 μM and 3.87 μM in BxPc-3 and Panc-1 cells, respectively[1].
In BxPc-3, Panc-1, and SW1990 cells, LB-100 treatment reduced PP2A activity by 30-50%. LB-100 increases the intracellular doxorubicin concentration (about 2.5 times that of the control group) and makes tumor cells more sensitive to the cytotoxicity of doxorubicin[1].
In a PANC-1 mouse xenograft model, LB-100 (2 mg / kg, intraperitoneal injection) improves the efficacy of the chemotherapy drug doxorubicin. LB-100 increases tumor microvessel density and blood flow velocity on the tumor surface, and decreases tumor volume[1].
Reference:
[1]. Bai X, Zhi X, Zhang Q, et al. Inhibition of protein phosphatase 2A sensitizes pancreatic cancer to chemotherapy by increasing drug perfusion via HIF-1α-VEGF mediated angiogenesis. Cancer Lett, 2014, 355(2): 281-287.
产品性质
| 物理外观 | A solid |
| CAS号 | 1632032-53-1 |
| 分子式 | C13H20N2O4 |
| 分子量 | 268.31 |
| 化学名称 | 3-(4-methylpiperazine-1-carbonyl)-7-oxabicyclo[2.2.1]heptane-2-carboxylic acid |
| 溶解度 | ≥26.8 mg/mL in H2O; insoluble in EtOH; insoluble in DMSO |
| SMILES | CN(CC1)CCN1C(C(C1OC2CC1)C2C(O)=O)=O |
| 存储条件 | -20°C |
| 运输条件 | 蓝冰 |
产品应用 (实验数据来自文献，APExBIO并未验证，仅供参考)
IC50和靶点
| 生物活性描述 | LB-100 是一种蛋白磷酸酶 2A (PP2A) 抑制剂，在 BxPc-3 和 Panc-1 细胞中的 IC50 分别为 0.85 μM 和 3.87 μM。 |
| 靶点 | Protein Ser/Thr Phosphatases |
生物相关数据
操作说明
APExBIO 顾客使用本产品发表的 2 篇科研文献
- 1. Yuan Fu, Xiaofan Jia, et al. "Fam72a functions as a cell-cycle-controlled gene during proliferation and antagonizes apoptosis through reprogramming PP2A substrates." Dev Cell. 2023 Mar 13;58(5):398-415.e7. PMID: 36868233
- 2. Gulisudumu Maitiabula, Feng Tian, et al. " Liver PP2A-Cα protects from parenteral nutrition-associated hepatic steatosis." Cell Mol Gastroenterol Hepatol. 2022 May 26;S2352-345X(22)00090-X. PMID: 35643235
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