Kainic acid
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Kainic acid（红藻氨酸）是一种选择性的kainate receptor（红藻氨酸受体）激动剂[1]。
红藻氨酸受体是一种离子型受体，对谷氨酸做出响应。突触前红藻氨酸受体调节GABA的释放，参与抑制性神经传递。突触后红藻氨酸受体参与兴奋性神经传递。
在老年大鼠中，kainic acid显著减少全面性强直-阵挛发作的潜伏期，增加癫痫大鼠的数量。在强直-阵挛发作的老年大鼠中，kainic acid也可以显著增加去甲肾上腺素（NE）、ASP 和GLU的释放[1]。在新生大鼠中，海马内注射kainic acid（1 μg）显著诱导锥体细胞死亡[2]。在成年大鼠中，kainic acid显著增加背角和脊髓白质中神经营养因子-4/5（NT-4/5）的mRNA水平以及腹角中脑源性神经营养因子（BDNF）的mRNA水平，而对神经营养因子-3（NT-3）没有影响。这些结果表明，NT-4/5和BDNF参与脊髓对kainic acid诱导的兴奋性毒性刺激的反应[3]。
参考文献：
[1]. Dawson R Jr, Wallace DR. Kainic acid-induced seizures in aged rats: neurochemical correlates. Brain Res Bull, 1992, 29(3-4): 459-468.
[2]. Cook TM, Crutcher KA. Intrahippocampal injection of kainic acid produces significant pyramidal cell loss in neonatal rats. Neuroscience, 1986, 18(1): 79-92.
[3]. Scarisbrick IA, Isackson PJ, Windebank AJ. Differential expression of brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4/5 in the adult rat spinal cord: regulation by the glutamate receptor agonist kainic acid. J Neurosci, 1999, 19(18): 7757-7769.
| Physical Appearance | A solid |
| Storage | Store at RT |
| M.Wt | 213.23 |
| Cas No. | 487-79-6 |
| Formula | C10H15NO4 |
| Solubility | ≥11.05 mg/mL in H2O with gentle warming |
| Chemical Name | (2S,3S,4S)-3-(carboxymethyl)-4-(prop-1-en-2-yl)pyrrolidine-2-carboxylic acid |
| SDF | Download SDF |
| Canonical SMILES | OC([C@H]1NC[C@H](C(C)=C)[C@@H]1CC(O)=O)=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
化学结构
