Escitalopram Oxalate
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Escitalopram Oxalate(Lexapro\Cipralex)是一种血清素(5-HT)再吸收的选择性抑制剂(SSRI),对[3H]-5-HT吸收的Ki值为6.6 nM[1].
Escitalopram Oxalate是西酞普兰的S-(+)-对映体,在表达人类血清素转运子(5-HTT)的COS-1细胞中可抑制[3H]-5-HT吸收和[125I]-RTI-55结合,Ki值分别为6.6±1.4 nM和3.9±2.2 nM.此外,Escitalopram Oxalate可在体外抑制3H标记的单胺在大鼠脑突触体的积累,对[3H]-5-HT\[3H]-I-NA和[3H]-DA的IC50值分别为2.1±0.75 nM\ 2500±202 nM和40000±15500 nM.除此之外,Escitalopram Oxalate对大鼠组胺H1受体和大鼠σ1位点具有体外亲和性,Ki值分别为1500±780 nM和100±71 nM[1].
参考文献：
[1] Sánchez C1, Bergqvist PB, Brennum LT, Gupta S, Hogg S, Larsen A, Wiborg O. Escitalopram, the S-(+)-enantiomer of citalopram, is a selective serotonin reuptake inhibitor with potent effects in animal models predictive of antidepressant and anxiolytic activities. Psychopharmacology (Berl). 2003 Jun;167(4):353-62. Epub 2003 Apr 26.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 414.43 |
| Cas No. | 219861-08-2 |
| Formula | C22H23FN2O5 |
| Solubility | ≥10.6 mg/mL in H2O; ≥2.31 mg/mL in EtOH with ultrasonic; ≥41.45 mg/mL in DMSO |
| Chemical Name | (1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-3H-2-benzofuran-5-carbonitrile;oxalic acid |
| SDF | Download SDF |
| Canonical SMILES | CN(C)CCCC1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F.C(=O)(C(=O)O)O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
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化学结构
