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Caspase

Caspases (cysteine-dependent aspartate specific ptotease) are a family of cysteine proteases that play an essential role in cell apoptosis. Caspases contain a conserved QACXG pentapeptide active site motif and are characterized by specificity for aspartic acid in the P1 position. The synthesis of caspases involves the activation of inactive proenzymes, which contain an N-terminal peptide (prodomain) together with two subunits (one small and one large), following cleavage at specific aspartate cleavage sites. Caspases can be classified into three subfamilies, due to phylogenetic analysis, including an ICE subfamily (caspases-1, -4 and -5), a CED-3/CPP32 subfamily (caspases-3, -6, -7, -8, -9 and -10) and an ICH-1/Nedd2 subfamily (caspase-2).

生化试剂

  1. 产品编号 产品名称 信息
  2. A1901 Q-VD-OPh hydrate Top Seller Pan-caspase抑制剂。
  3. A1902 Z-VAD-FMK Top Seller Pan-Caspase抑制剂。
  4. A1920 Z-DEVD-FMK Top Seller Caspase-3抑制剂
  5. A1925 Caspase-3/7 Inhibitor I Top Seller Caspase-3/7抑制剂
  6. A9901 Caspase Inhibitor Set I Contains 25µl (10mM) each of the following inhibitors: A1902 Z-VAD-FMK, A1901 Q-VD-OPH, A1920 Z-DEVD-FMK,A8321 Cisplatin
  7. A8238 VX-765 有效的Caspase-1选择性抑制剂
  8. A1923 Z-VEID-FMK Top Seller Caspase-6抑制剂
  9. A1922 Z-VDVAD-FMK Top Seller Caspase-2抑制剂
  10. A1921 Z-DQMD-FMK Top Seller 细胞渗透性Caspase-3抑制剂
  11. B3232 Z-IETD-FMK Caspase-8抑制剂
  12. A8165 Q-VD(OMe)-OPh Top Seller Pan-caspase抑制剂
  13. B3233 Z-LEHD-FMK 不可逆的Caspase-9抑制剂
  14. A8321 Cisplatin Top Seller 化疗药物,抑制DNA合成
  15. A8177 PAC-1 Top Seller 半胱天冬酶-3酶原激活剂
  16. A8170 Z-FA-FMK Top Seller 半胱氨酸蛋白酶抑制剂
  17. A4016 Apoptosis Activator 2 吲哚二酮caspase激活剂
  18. A4420 PETCM Caspase-3激活剂
  19. A1930 Apoptosis Inhibitor Top Seller 与caspase-3的抑制相关
  20. A4417 Ivachtin Caspase-3抑制剂
  21. A4416 AZ 10417808 Caspase-3抑制剂
  22. A1904 Boc-D-FMK 广谱caspase抑制剂
  23. A4419 Ac-LEHD-AFC 荧光caspase底物
  24. A1924 Z-WEHD-FMK 强效、细胞渗透性和不可逆性的Caspase 5抑制剂
  25. A3424 Gambogic Acid Caspase激活剂和凋亡诱导剂
  26. A4418 Ac-IEPD-AFC 丝氨酸蛋白酶granzyme B的识别基序