ZLDI-8
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
ZLDI-8是Notch激活/切割酶ADAM-17的抑制剂。它抑制Notch蛋白的切割，从而降低了促生存/抗凋亡和EMT相关蛋白的表达。在不同时间点，用不同浓度的ZLDI-8处理MHCC97-H细胞，数据显示，ZLDI-8的IC50值为5.32 ± 0.46 μmol/L：ZLDI-8在3 μmol/L、10 μmol/L和30 μmol/L浓度时，对MHCC97-H细胞产生了细胞毒性作用，但在1 μmol/L浓度时不存在。 ZLDI-8 治疗增强了肝癌细胞对小分子激酶抑制剂索拉非尼、化疗药物依托泊苷和紫杉醇的敏感性。 ZLDI-8 治疗还增强了索拉非尼在肝细胞癌裸鼠模型中抑制肿瘤生长的作用。
1. Zhang Y, et al. Novel ADAM-17 inhibitor ZLDI-8 enhances the in vitro and in vivo chemotherapeutic effects of Sorafenib on hepatocellular carcinoma cells. Cell Death Dis. 2018 Jul 3;9(7):743.
| Storage | Store at -20°C |
| M.Wt | 433.52 |
| Cas No. | 667880-38-8 |
| Formula | C24H23N3O3S |
| Solubility | ≥22.45 mg/mL in DMSO |
| Chemical Name | 5-((1-(2-(2,4-dimethylphenoxy)ethyl)-2-methyl-1H-indol-3-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione |
| SDF | Downlo |
| Canonical SMILES | O=C1/C(C(NC(N1)=S)=O)=C\C2=C(C)N(CCOC3=CC=C(C)C=C3C)C4=C2C=CC=C4 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
