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Trimidox

 
Catalog No.
C4764
特异性核糖核苷酸还原酶抑制剂
组合的产品项目
规格价格库存 数量
5mg
¥ 1,191.00
Ship with 10-15 days
10mg
¥ 2,220.00
Ship with 10-15 days
50mg
¥ 7,095.00
Ship with 10-15 days
100mg
¥ 12,404.00
Ship with 10-15 days

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A

背景

Trimidox (3.4.5-tri-hydroxybenzohydroxamidoxime) is a specific and patented ribonucleotide reductase (RNR) inhibitor [1].

Ribonucleotide reductase (RNR), also known as ribonucleoside diphosphate reductase, is an enzyme involved in catalyzing the formation of deoxyribonucleotides from ribonucleotides. RNR plays a vital role in regulating the total rate of DNA synthesis to DNA to maintain DNA cell mass a constant ratio during cell division and DNA repair. The substrates for RNR are ADP, GDP, CDP and UDP [2]. Increased ribonucleotide reductase (RNR) activity has been associated with malignant transformation and tumor cell growth [1].

In human promyelocytic leukemia HL-60 cells, trimidox inhibited the growth of with an IC50 of 35 pmol/L. Treatment with trimidox (50 pmol/L) for 24 hours decreased deoxyguanosine triphosphate (dGTP) and deoxycytidine triphosphate (dCTP) pools to 24% and 3946 of control values, respectively. Incubation of HL-60 cells with 20 to 80 pmol/L trimidox to 4 days showed no effects in the distribution of cells indifferent phases of cell cycle [1]. Trimidox in combination with tiazofurin was useful in the treatment of leukemia [1].

References:
[1] Szekeres T, Fritzer M, Strobl H, et al.  Synergistic growth inhibitory and differentiating effects of trimidox and tiazofurin in human promyelocytic leukemia HL-60 cells[J]. Blood, 1994, 84(12): 4316-4321.
[2] Elledge S J, Zhou Z, Allen J B.  Ribonucleotide reductase: regulation, regulation, regulation[J]. Trends in biochemical sciences, 1992, 17(3): 119-123.

化学属性

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt184.2
Cas No.95933-74-7
FormulaC7H8N2O4
SynonymsVF 233
Solubility≤20mg/ml in DMSO;20mg/ml in dimethyl formamide
Chemical NameN,3,4,5-tetrahydroxy-benzenecarboximidamide
SDFDownload SDF
Canonical SMILESOC1=C(O)C(O)=CC(C(NO)=N)=C1
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质量控制

质量控制和MSDS

批次:

化学结构

Trimidox