TH34
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
TH34是HDAC6/8/10的抑制剂，IC50值分别为4.6 μM、1.9 μM、7.7 μM，与HDAC1/2/3 相比，显示出高选择性。TH34消除高级成神经细胞瘤细胞，而对未转化的人源细胞无影响。TH34在几种人类神经母细胞瘤细胞系中以浓度依赖性方式诱导caspase依赖的程序性细胞死亡[1]。
参考文献：
[1]. Kolbinger FR, et al. The HDAC6/8/10 inhibitor TH34 induces DNA damage-mediated cell death in human high-grade neuroblastoma cell lines. Arch Toxicol. 2018 Aug;92(8):2649-2664. PMID: 29947893
| Storage | Store at -20°C |
| M.Wt | 256.31 |
| Cas No. | 2196203-96-8 |
| Formula | C15H16N2O2 |
| Solubility | ≥25.9 mg/mL in DMSO |
| Chemical Name | 3-(benzylamino)-N-hydroxy-4-methylbenzamide |
| SDF | Download SDF |
| Canonical SMILES | O=C(NO)C1=CC=C(C)C(NCC2=CC=CC=C2)=C1 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
