TH287
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
TH287是MTH1的有效抑制剂,IC50为0.8 ± 0.1 nM[1].
MTH1(人Mutt的同系物1)是抗突变的嘌呤核苷三磷酸酶,用于审查氧化核苷酸库.MTH1是一个新的癌症治疗靶标,可以防止癌细胞发生DNA损伤,如氧化应激诱导的细胞功能障碍或细胞死亡.
在U2OS和其它癌细胞系中,TH287选择性地有效杀死癌细胞,对一些原代的或无限增殖的细胞有较少毒性.TH287处理U2OS细胞,DNA的8-oxodG增加.在U2OS细胞中,MTH1抑制剂TH287诱导DNA损伤,激活ATM-p53介导的死亡应答和DNA修复[1].
参考文献:
1. Gad H, Koolmeister T, Jemth AS et al. MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature. 2014 Apr 10;508(7495):215-21.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 269.13 |
Cas No. | 1609960-30-6 |
Formula | C11H10Cl2N4 |
Solubility | ≥55.56 mg/mL in DMSO; insoluble in H2O; ≥2.33 mg/mL in EtOH with ultrasonic |
Chemical Name | 6-(2,3-dichlorophenyl)-N4-methylpyrimidine-2,4-diamine |
SDF | Download SDF |
Canonical SMILES | ClC1=C(Cl)C(C2=CC(NC)=NC(N)=N2)=CC=C1 |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
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