SU1498

mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail

Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.

Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody

Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay

SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.

Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
SU1498(AG1498)是选择性的VEGFR2抑制剂;抑制Flk-1的IC50值为700 nm[1]。SU1498用来研究VEGFR2信号在血管生成、肿瘤生长、神经前体细胞生存和神经再生等不同过程中的功能。SU1498刺激人脐静脉内皮细胞和人主动脉内皮细胞中磷酸化ERKs的积累,其方式依赖于MAPK途径的上游成分、B-Raf和MEK激酶的功能。磷酸化ERKs的增强积累只在受到1-磷酸鞘氨醇或蛋白生长因子刺激的细胞中观察到;SU1498本身是无效的[2]。SU1498(AG1498)在体外和体内都能有效阻断通过VEGFR2的信号传导。
参考文献:
[1]. Strawn LM, McMahon G, App H, Schreck R, Kuchler WR, Longhi MP, Hui TH, Tang C, Levitzki A, Gazit A, Chen I, Keri G, Orfi L, Risau W, Flamme I, Ullrich A, Hirth KP, Shawver LK. Flk-1 as a target for tumor growth inhibition. Cancer Res. 1996 Aug 1;56(15):3540-5. PMID: 8758924.
[2]. Boguslawski G, McGlynn PW, Harvey KA, Kovala AT. SU1498, an inhibitor of vascular endothelial growth factor receptor 2, causes accumulation of phosphorylated ERK kinases and inhibits their activity in vivo and in vitro. J Biol Chem. 2004 Feb 13;279(7):5716-24. doi: 10.1074/jbc.M308625200. Epub 2003 Nov 18. PMID: 14625306.
Storage | Store at -20°C |
M.Wt | 390.52 |
Cas No. | 168835-82-3 |
Formula | C25H30N2O2 |
Synonyms | AG 1498,Tyrphostin SU 1498 |
Solubility | ≥36.5 mg/mL in DMSO |
Chemical Name | (E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropyl)acrylamide |
SDF | Download SDF |
Canonical SMILES | O=C(/C(C#N)=C/C1=CC(C(C)C)=C(C(C(C)C)=C1)O)NCCCC2=CC=CC=C2 |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
