SRT1720是一个可以活化沉默调节蛋白SIRT1的小分子化合物。作为SIRT1的激活剂，SRT1720比resveratrol的作用更强。SRT1720以Sirt1 和PGC-1α依赖的方式影响线粒体呼吸。据报道，SRT1720可以增加胰岛素的敏感性，提高线粒体容量和氧化代谢。在多发性骨髓瘤（MM）细胞中，SRT1720抑制细胞的生长，诱导MM细胞的凋亡，但对正常细胞的细胞活力没有显著影响。SRT1720能够增强bortezomib或dexamethasone的细胞毒性效应。SRT1720的抗MM活性与以下几个方面相关：1）激活caspase-8，caspase-9，caspase-3, 聚（ADP-核糖）聚合酶（PARP）；2）增加活性氧；3)诱导磷酸共济失调毛细血管扩张突变/检验点激酶2信号；4）减少血管内皮细胞生长因子诱导的MM细胞的迁移及相关的血管生成；5）抑制核因子κB。

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