Picolinamide
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Picolinamide是一种聚(ADP-核糖)合成酶(PARP)抑制剂。
PARP抑制剂是一组聚ADP核糖聚合酶(PARP)的药理学抑制剂,研究用于多种适应症,特别是用于治疗癌症。
体外:已经研究阐明了革兰氏阴性杆菌氧化Picolinamide的途径。结果表明,在高pH条件下,全细胞可以释放2,5-二羟基吡啶到培养上清液中。此外,亚砷酸钠能够使全细胞在培养基中积累6-羟基吡啶甲酸。此外,发现全细胞氧化Picolinamide而没有滞后。研究还发现无细胞提取物可将Picolinamide转化为吡啶甲酸盐,并将吡啶甲酸盐羟基化转化成6-羟基吡啶甲酸盐[1]。
体内:在先前的研究中使用Picolinamide以评价Na + /磷酸盐共转运的抑制可能与NAD水解酶的抑制相关的可能性。结果表明,对大鼠Picolinamide单次注射(4 mmol/kg)给药的过夜处理可以抑制分离的肾刷状缘膜囊泡对Na+/磷酸盐的共转运。与烟酰胺类似,在甲状腺切除大鼠中由Picolinamide引起的抑制,对Na+/磷酸盐共转运是特异性的。与烟酰胺不同,picolinamide治疗后肾皮质NAD含量仅有1.5倍的增加[2]。
临床试验:到目前为止,Picolinamide仍处于临床前研究阶段。
参考文献:
[1] C. G. Orpin,M. Knight, andW. C. Evans. The bacterial oxidation of picolinamide, a photolytic product of DiquatBiochem J. 1972 May; 127(5): 819–831.
[2] Campbell PI,al-Mahrouq HA,Abraham MI,Kempson SA. Specific inhibition of rat renal Na+/phosphate cotransport by picolinamide. J Pharmacol Exp Ther.1989 Oct;251(1):188-92.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 122.12 |
Cas No. | 1452-77-3 |
Formula | C6H6N2O |
Solubility | ≥83.33 mg/mL in DMSO; insoluble in H2O; ≥14.54 mg/mL in EtOH |
Chemical Name | picolinamide |
SDF | Download SDF |
Canonical SMILES | NC(C1=CC=CC=N1)=O |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
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