NG 52
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
NG 52是Cdc28p和Pho85p激酶的有效选择性抑制剂，IC50值分别为7 μM和2 μM。NG 52具有口服活性和ATP相容性[1]。NG 52可以剂量依赖性抑制胶质瘤U87和U251细胞系和原代神经胶质瘤细胞的增殖。口服NG 52 (50-150 mg/kg)治疗剂量依赖性地抑制神经胶质瘤异种移植物的生长[2]。
参考文献：
[1]. ray NS, Wodicka L, Thunnissen AM et al. Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science. 1998 Jul 24;281(5376):533-8. PMID: 9677190
[2]. Wen-Liang Wang, et al. Pharmacologically inhibiting phosphoglycerate kinase 1 for glioma with NG52. Acta Pharmacol Sin. 2020 Jul 31. PMID: 32737469
| Storage | Store at -20°C |
| M.Wt | 346.81 |
| Cas No. | 212779-48-1 |
| Formula | C16H19ClN6O |
| Synonyms | Compound 52 |
| Solubility | ≥19 mg/mL in DMSO |
| Chemical Name | 2-((6-((3-chlorophenyl)amino)-9-isopropyl-9H-purin-2-yl)amino)ethanol |
| SDF | Download SDF |
| Canonical SMILES | ClC1=CC(NC2=NC(NCCO)=NC3=C2N=CN3C(C)C)=CC=C1 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
