Myoseverin
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
IC50为16 nM。
Myoseverin是一种新型微管结合分子。
微管是由微管蛋白组成的动态丝状细胞骨架蛋白,是肿瘤细胞中的关键治疗靶点。与微管结合的药物数十年来一直是抗癌治疗的一线标准,直到靶向治疗出现。
体外:Myoseverin能够诱导多核肌管可逆地分裂成单核片段。此外,去除myoseverin并将细胞转移到新鲜生长培养基后,细胞增殖和肌管裂变促进DNA合成。此外,生化分析和转录谱表明单独的myoseverin不能逆转生化分化的过程。然而,myoseverin可以影响多种生长因子、细胞外基质重塑、免疫调节性以及应激反应基因的表达,这与参与组织再生和伤口愈合的通路的活化一致[1]。另一项研究发现,myoseverin处理的心肌细胞表现出对具有α-辅肌动蛋白和结蛋白的条纹状Z-带的破坏。类似地,活性stathmin的表达不能阻止肌节的装配。此外,由myoseverin和nocodazole引起的MT去稳定的程度是相当的[2]。
体内:目前尚无动物体内数据报道。
临床试验:到目前为止,myoseverin仍处于临床前研究阶段。
参考文献:
[1] Rosania GR,Chang YT,Perez O,Sutherlin D,Dong H,Lockhart DJ,Schultz PG. Myoseverin, a microtubule-binding molecule with novel cellular effects. Nat Biotechnol.2000 Mar;18(3):304-8.
[2] Ng DC,Gebski BL,Grounds MD,Bogoyevitch MA. Myoseverin disrupts sarcomeric organization in myocytes: an effect independent of microtubule assembly inhibition. Cell Motil Cytoskeleton.2008 Jan;65(1):40-58.
Physical Appearance | A crystalline solid |
Storage | Store at -20°C |
M.Wt | 432.52 |
Cas No. | 267402-71-1 |
Formula | C24H28N6O2 |
Solubility | Soluble in DMSO |
Chemical Name | (E)-9-isopropyl-N-(4-methoxybenzyl)-2-((4-methoxybenzyl)imino)-2,9-dihydro-1H-purin-6-amine |
SDF | Download SDF |
Canonical SMILES | CC(N1C=NC(C1=N/C2=N/CC3=CC=C(OC)C=C3)=C(N2)NCC4=CC=C(OC)C=C4)C |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |