MN 64
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
MN-64是一类黄酮,用作一种强效的和选择性的tankyrase抑制剂(作用于TNKS1和TNKS2的IC50分别为6和72 nM).[1]
Tankytase (TNKS)是聚ADP核糖聚合酶(PARPs)的成员之一.两个相关的同系物TNKS1和TNKS2大多位于核孔\细胞质\有丝分裂中心体和高尔基体.它们参与细胞功能,如人类细胞中调节细胞增殖和促进端粒延伸.[1]
在筛选黄酮TNKS抑制剂的实验中,发现200 nM 的MN-64去除STF萤光素酶活性并强效抑制TNKS1,IC50为6 nM.MN-64还选择性地抑制TNKS1和TNKS2而不影响任何其他PARPs.此外,MN-64比其他TNKS抑制剂如XAV939更具选择性.[1]
参考文献：
1. Narwal M, Koivunen J, Haikarainen T et al. Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. J Med Chem. 2013 Oct 24;56(20):7880-9.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 264.32 |
| Cas No. | 92831-11-3 |
| Formula | C18H16O2 |
| Solubility | insoluble in H2O; ≥11.65 mg/mL in DMSO; ≥25.9 mg/mL in EtOH |
| Chemical Name | 2-(4-isopropylphenyl)-4H-chromen-4-one |
| SDF | Download SDF |
| Canonical SMILES | CC(C1=CC=C(C2=CC(C3=CC=CC=C3O2)=O)C=C1)C |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
