KX1-004
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
KX1-004是一种非ATP竞争性的pp60c-src抑制剂,IC50值为40 μM[1].
KX1-004是已报道的基于吲哚的Src-PTK抑制剂的紧密类似物.该物质具有5-氟基团,在分离的Src-PTK试验中具有有效的抑制活性.KX1-004对噪声性听力损失有保护功能.经30 μM的KX1-004处理的毛丝鼠暴露于持续噪声中.结果表明经治疗的耳朵相对于对照组耳朵存在高达40 dB更少的暂时性阈移(TTS)和高达25 dB更少的永久性阈移(PTS).KX1-004处理相对于对照组也显著减少外毛细胞(OHC)损失.此外,KX1-004可显著减少脉冲噪声暴露相关的听力损失和毛细胞损失[1,2].
参考文献：
[1] Harris K C, Hu B, Hangauer D, et al. Prevention of noise-induced hearing loss with Src-PTK inhibitors. Hearing research, 2005, 208(1): 14-25.
[2] Milkiewicz K L, Marsilje T H, Woodworth Jr R P, et al. The design, synthesis and activity of non-ATP competitive inhibitors of pp60 c-src tyrosine kinase. Part 2: Hydroxyindole derivatives. Bioorganic & medicinal chemistry letters, 2000, 10(5): 483-486.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 284.29 |
| Cas No. | 518058-84-9 |
| Formula | C16H13FN2O2 |
| Solubility | insoluble in H2O; ≥10.1 mg/mL in DMSO; ≥3.55 mg/mL in EtOH with gentle warming and ultrasonic |
| Chemical Name | 5-fluoro-N-(3-hydroxybenzyl)-1H-indole-2-carboxamide |
| SDF | Download SDF |
| Canonical SMILES | FC1=CC(C=C(C(NCC2=CC=CC(O)=C2)=O)N3)=C3C=C1 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
