INH14
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
INH14是IKKα/β依赖性TLR炎症反应的抑制剂，INH14抑制IKKα/IKKβ的IC50值分别为8.97 和3.59 μM。INH14抑制TAK1/TAB1复合物的下游，导致作为TLR2通路一部分的蛋白质过度表达。在小鼠中，INH14处理减少了脂肽诱导炎症后TNFα的形成，INH14处理卵巢癌细胞降低了NF-kB成分活性和细胞的伤口闭合能力[1]。
参考文献：
[1]. Drexel M, et al. INH14, a Small-Molecule Urea Derivative, Inhibits the IKKα/β-Dependent TLR Inflammatory Response. Chembiochem. 2019 Mar 1;20(5):710-717. PMID: 30447158
| Storage | Store at -20°C |
| M.Wt | 240.31 |
| Cas No. | 200134-22-1 |
| Formula | C15H16N2O2 |
| Solubility | ≥36 mg/mL in DMSO |
| Chemical Name | 1-(4-ethylphenyl)-3-phenylurea |
| SDF | Download SDF |
| Canonical SMILES | O=C(NC1=CC=CC=C1)NC2=CC=C(CC)C=C2 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
