HAMNO
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
HAMNO (NSC-111847) 是一种有效的、选择性的、具有抗肿瘤活性的replication protein A (RPA)的抑制剂。 HAMNO可抑制ATR的自磷酸化及ATR诱导的RPA32 Ser33磷酸化。HAMNO HNSCC细胞系中的菌落形成。HAMNO与依托泊苷的组合比单独使用HAMNO在更大程度上显着抑制菌落形成。在UMSCC38细胞中,HAMNO 剂量依赖性地增加了泛核γ-H2AX染色的发生。UMSCC38和UMSCC11B细胞具有显着的γ-H2AX染色,尤其是在与HAMNO(20 μM)孵育后。在UMSCC38和OKF4细胞中,HAMNO增加了γ-H2AX染色,S期信号增加最大。在小鼠中,HAMNO抑制UMSCC11B肿瘤的进展。用依托泊苷(20μM,2小时)处理后,RPA32(一种ATR底物)的Ser33高度磷酸化,添加2 μM HAMNO后会降低,并且在较高浓度下几乎不存在,表明HAMNO可以通过ATR抑制RPA32磷酸化[1]。
参考文献:
[1]. Glanzer JG, Liu S, Wang L, Mosel A, Peng A, Oakley GG. RPA inhibition increases replication stress and suppresses tumor growth. Cancer Res. 2014 Sep 15;74(18):5165-72. doi: 10.1158/0008-5472.CAN-14-0306. Epub 2014 Jul 28. PMID: 25070753; PMCID: PMC4201622.
Storage | Store at -20°C |
M.Wt | 263.3 |
Cas No. | 138736-73-9 |
Formula | C17H13NO2 |
Synonyms | NSC111847 |
Solubility | ≥26.5 mg/mL in DMSO |
Chemical Name | (Z)-1-(((2-hydroxyphenyl)amino)methylene)naphthalen-2(1H)-one |
SDF | Download SDF |
Canonical SMILES | O=C(C=CC1=C/2C=CC=C1)C2=C/NC3=CC=CC=C3O |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
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